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SARS-CoV-2 proteins

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    A false alarm of COVID-19 MESHD pneumonia in lung cancer: a case report of anti-PD-1 related pneumonitis and literature review

    Authors: Ying Dai; Ying Dai; Sha Liu; Sha Liu; Zhiyan Zhao; Zhiyan Zhao; Xiaqiu Li; Xiaqiu Li; Yiruo Zhang; Yiruo Zhang; Pingping Liu; Pingping Liu; Yingying Du; Yingying Du

    doi:10.21203/rs.3.rs-41095/v1 Date: 2020-07-11 Source: ResearchSquare

    Background: The fatal toxicity MESHD of anti-PD-1/ PD-L1 HGNC agents is pneumonitis MESHD. The diagnosis consists of the history of immunotherapy, clinical symptoms and presentation of computed tomography (CT) imaging. The typical CT findings include ground-glass opacities. Based on the similar radiographic feature with 2019 Novel Coronavirus ( COVID-19 MESHD) pneumonia MESHD, clinicians are cautious to evaluate diagnosis especially in COVID-19 MESHD epidemic areas. Case presentation: Herein we report a 67-year-old male patient with advanced non-small cell lung cancer MESHD developed pneumonitis MESHD post Sintilimab injection. The dyspnea MESHD appeared at the 15th day of close contact with his son who returned from Wuhan, but not accompanied with fever MESHD. The chest CT indicated peripherally subpleural lattice opacities at the inferior right lung lobe and bilateral thoracic infusion. The real-time reverse-transcription polymerase-chain-reaction (RT-PCR) from double swab samples within 72 hours remained negative. The patient was thereafter treated with prednisolone and antibiotics for over two weeks. Thereafter the chest CT demonstrated the former lesion almost absorbed, in line with prominently falling CRP HGNC level. The anti-PD-1 related pneumonitis MESHD with bacterial infection MESHD was diagnosed finally based on the clinical evidence and good response to the prednisolone and antibiotics. Conclusion: Both ani-PD-1 related pneumonitis MESHD and COVID-19 MESHD pneumonia harbor the common clinical symptom and the varied features of CT imaging. Differential diagnosis was based on the epidemiological and immunotherapy histories, RT-PCR tests. The response to glucocorticoid can indirectly help the diagnosis.

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MeSH Disease
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