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HGNC Genes

SARS-CoV-2 proteins

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    The Age Again in The Eye of The Covid-19 MESHD Storm: Evidence-Based Decision Making.

    Authors: M. Carmen Martín; Aurora Jurado; Cristina Abad-Molina; Antonio Orduña; Oscar Yarce; Ana M. Navas; Vanesa Cunill; Danilo Escobar; Francisco Boix; Sergio Burillo-Sanz; María C. Vegas-Sánchez; Yesenia Jiménez-de las Pozas; Josefa Melero; Marta Aguilar; Oana Irina Sobieschi; Marcos López-Hoyos; Gonzalo Ocejo-Vinyals; David San Segundo; Delia Almeida; Silvia Medina; Luis Fernández-Pereira; Esther Vergara; Bibiana Quirant; Eva Martínez-Cáceres; Marc Boigues; Marta Alonso; Laura Esparcia-Pinedo; Celia López-Sanz; Javier Muñoz-Vico; Serafín López-Palmero; Antonio Trujillo; Paula Álvarez; Álvaro Prada; David Monzón; Jesús Ontañón; Francisco M. Marco; Sergio Mora; Ricardo Rojo; Gema González-Martínez; María T. Martínez-Saavedra; Juana Gil-Herrera; Sergi Cantenys-Molina; Manuel Hernández; Janire Perurena-Prieto; Beatriz Rodríguez-Bayona; Alba Martínez; Esther Ocaña; Juan Molina

    doi:10.21203/rs.3.rs-228480/v1 Date: 2021-02-10 Source: ResearchSquare

    Background: One hundred million of contagions, more than 2 million deaths and less than one year of COVID-19 MESHD have changed our lives and our health management systems forever. Ageing is known to be one of the significant determinants for COVID-19 MESHD severity. Two main reasons underlie this: immunosenescence and age correlation with main COVID-19 MESHD comorbidities such as hypertension or dyslipidaemia MESHD. This study has two aims. The first is to obtain cut-off points for laboratory parameters that can help us in clinical decision-making. The second one is to analyse the effect of pandemic lockdown on epidemiological, clinical, and laboratory parameters concerning the severity of the COVID-19 MESHD. For these purposes, 257 of SARSCoV2 inpatients during pandemic confinement were included in this study. Moreover, 584 case records from a previously analysed series, were compared with the present study data. Results: Concerning the characteristics of lockdown series, mild cases accounted for 14.4%, 54.1% were moderate and 31.5%, severe. There were 32.5% of home contagions, 26.3% community transmissions, 22.5% nursing home contagions, and 8.8% corresponding to frontline worker contagions regarding epidemiological features. Age >60 and male sex are hereby confirmed as severity determinants. Equally, higher severity was significantly associated with higher IL6 HGNC, CRP HGNC, ferritin, LDH, and leukocyte counts, and a lower percentage of lymphocyte, CD4 HGNC and CD8 HGNC count. Comparing this cohort with a previous 584-cases series, mild cases were less than those analysed in the first moment of the pandemic and dyslipidaemia became more frequent than before. Age, lymphocyte count and LDH had similar distributions at both moments. IL-6 HGNC, CRP HGNC and LDH values above 69 pg/mL, 97 mg/L and 328 U/L respectively, as well as a CD4 HGNC T-cell count below 535 cells/μL, were the best cut-offs predicting severity since these parameters offered reliable areas under the curve. Conclusion: Age, sex and dyslipidaemia together with selected laboratory parameters on admission can help us predict COVID-19 MESHD severity and, therefore, make clinical and resource management decisions. Demographic features associated with lockdown could affect the homogeneity of the data and the robustness of the results.

    Relationship between the dynamic changes of serum 2019-nCoV IgM/IgG and patient immunity after discharged six months

    Authors: Yinfeng Shen; Yuanming Ba; Yaling Hu; Linqun Wang; Weinan Li

    doi:10.21203/rs.3.rs-84754/v1 Date: 2020-09-28 Source: ResearchSquare

    Objectives To investigate the relationship between the dynamic changes of serum 2019-nCoV IgM/IgG and immunity alteration for patients after discharged six months. Methods 1 with IgM(+) and IgG(-), 32 with IgM(+) and IgG(+), 38 with IgM(-) and IgG(+), and 40 with IgM(-) and IgG(-) were included. Demographic data were collected. IgM and IgG antibodies, hypersensitive C-reactive protein HGNC (hs-CRP), interleukin-6 HGNC ( IL-6 HGNC) and lymphocyte subsets in serum were determined on weeks 0, 2 and 4. Results Hs-CRP and IL-6 HGNC for all patients were within the normal ranges. All testing items of the lymphocyte subsets were 12/110 (10.9%) of weeks 0, 15/110 (13.6%) of weeks 2 and 18/110 (16.4%) of weeks 4 within the normal ranges. The percentages of CD8 HGNC+, NK cells and B lymphocytes in the IgM(+) and IgG(+) group were quite different from the IgM(-) and IgG(+) group and the IgM(-)and IgG(-) group, with much more the percentages of CD8 HGNC+ and much less the percentages of NK cells and B lymphocytes on weeks 0, 2 and 4. 12 patients with IgM(+) had converted to IgM(-) in the IgM(+) and IgG(+) group, and the percentages of NK cells and B lymphocytes were significantly increased on weeks 4.Conclusions The changes of serum IgM and IgG are closely related to immunity for patients in recovery stage. However, immunity isn't recovery with the turning negative of antibodies.

    Viral shedding and immunological features of children COVID-19 MESHD patients

    Authors: Yang Yang; Haixia Zheng; Ling Peng; Jinli Wei; Yanrong Wang; Xiaohe Li; Bo Peng; Shisong Fang; Mingxia Zhang; Hui Liu; Yanjie Li; Kai Feng; Li Xing; Jun Wang; Mengli Cao; Fuxiang Wang; Yingxia Liu; Lei Liu; Jing Yuan

    doi:10.1101/2020.08.25.20181446 Date: 2020-08-31 Source: medRxiv

    Abstract Background SARS-CoV-2 could infect people at all ages, and the viral shedding and immunological features of children COVID-19 MESHD patients were analyzed. Methods Epidemiological information and clinical data were collected from 35 children patients. Viral RNAs in respiratory and fecal samples were detected. Plasma of 11 patients were collected and measured for 48 cytokines. Results 40% (14/35) of the children COVID-19 MESHD patients showed asymptomatic infections, while pneumonia shown by CT scan occurred in most of the cases (32/35, 91.43%). Elevated LDH, AST HGNC, CRP HGNC, neutropenia, leukopenia, lymphopenia and thrombocytopenia occurred in some cases, and CD4 HGNC and CD8 HGNC counts were normal. A total of 22 cytokines were significantly higher than the healthy control, and IP-10 HGNC, IFN-2 of them in children were significantly lower than the adult patients. Meanwhile, MCP-3 HGNC, HGF HGNC, MIP-1 HGNC, and IL-1ra HGNC were similar or lower than healthy control, while significantly lower than adult patients. Viral RNAs were detected as early as the first day after illness onset (d.a.o) in both the respiratory and fecal samples. Viral RNAs decreased as the disease progression and mostly became negative in respiratory samples within 18 d.a.o, while maintained relatively stable during the disease progression and still detectable in some cases during 36~42 d.a.o. Conclusion COVID-19 MESHD in children was mild, and asymptomatic infection was common. Immune responses were relatively normal in children COVID-19 MESHD patients. Cytokine storm also occurred in children patients, while much weaker than adult patients. Positive rate of viral RNAs in fecal samples was high, and profile of viral shedding were different between respiratory and gastrointestinal tract.

    Viral shedding and immunological features of children COVID-19 MESHD patients

    Authors: Yang Yang; Haixia Zheng; Ling Peng; Jinli Wei; Yanrong Wang; Hexiao Li; Bo Peng; Shisong Fang; Mingxia Zhang; Yanjie Li; Hui Liu; Kai Feng; Li Xing; Jun Wang; Mengli Cao; Fuxiang Wang; Lei Liu; Yingxia Liu; Jing Yuan

    doi:10.21203/rs.3.rs-48544/v2 Date: 2020-07-24 Source: ResearchSquare

    Background SARS-CoV-2 could infect people at all ages, and the viral shedding and immunological features of children COVID-19 MESHD patients were analyzed.Methods Epidemiological information and clinical data were collected from 35 children patients. Viral RNAs in respiratory and fecal samples were detected. Plasma of 11 patients were collected and measured for 48 cytokines.Results 40% (14/35) of the children COVID-19 MESHD patients showed asymptomatic infections, while pneumonia MESHD shown by CT scan occurred in most of the cases (32/35, 91.43%). Elevated LDH, AST HGNC, CRP HGNC, neutropenia MESHD, leukopenia MESHD, lymphopenia MESHD and thrombocytopenia MESHD occurred in some cases, and CD4 HGNC and CD8 HGNC counts were normal. A total of 22 cytokines were significantly higher than the healthy control, and IP-10 HGNC, IFN-α2 HGNC of them in children were significantly lower than the adult patients. Meanwhile, MCP-3 HGNC, HGF HGNC, MIP-1α HGNC, and IL-1ra HGNC were similar or lower than healthy control, while significantly lower than adult patients. Viral RNAs were detected as early as the first day after illness onset (d.a.o) in both the respiratory and fecal samples. Viral RNAs decreased as the disease progression and mostly became negative in respiratory samples within 18 d.a.o, while maintained relatively stable during the disease progression and still detectable in some cases during 36~42 d.a.o. Conclusion COVID-19 MESHD in children was mild, and asymptomatic infection was common. Immune responses were relatively normal in children COVID-19 MESHD patients. Cytokine storm also occurred in children patients, while much weaker than adult patients. Positive rate of viral RNAs in fecal samples was high, and profile of viral shedding were different between respiratory and gastrointestinal tract.

    Laboratory findings in coronavirus disease 2019 MESHD ( COVID-19 MESHD) patients: a comprehensive systematic review and meta-analysis

    Authors: Mohammad Karimian; Amirreza Jamshidbeigi; Gholamreza Badfar; Milad Azami

    doi:10.1101/2020.06.07.20124602 Date: 2020-06-08 Source: medRxiv

    Background: In early December 2019, the first patient with COVID-19 MESHD pneumonia MESHD was found in Wuhan, Hubei Province, China. Recent studies have suggested the role of primary laboratory tests in addition to clinical symptoms for suspected patients, which play a significant role in the diagnosis of COVID-19 MESHD. Therefore, the present study was conducted to evaluate laboratory findings in COVID-19 MESHD patients. Material and methods: The present meta-analysis was reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. This protocol is registered with the code CRD42019145410 in PROSPERO International Database. Results: Finally, 52 studies involving 5490 patients with COVID-19 MESHD entered the meta-analysis process. The prevalence of leukopenia MESHD, lymphopenia MESHD, elevated c-reactive protein HGNC ( CRP HGNC), elevated erythrocyte sedimentation rate (ESR), elevated serum amyloid A, elevated ferritin was estimated to be 20.9% (95%CI: 17.9-24.3), 51.6% (95%CI: 44.0-59.1), 63.6% (95%CI: 57.0-69.8), 62.5% (95%CI: 50.1-73.5), 63.6% (95%CI: 57.0-69.8), 62.5% (95%CI: 50.1-73.5), 74.7% (95%CI: 50.0-89.7), and 72.6% (95%CI: 58.1-83.5), respectively. The prevalence of elevated interleukin-6 HGNC was 59.9% (95%CI: 48.2-70.5), CD3 was 68.3% (95%CI: 50.1-82.2), reduced CD4 HGNC was 62.0% (95%CI: 51.1-71.6), reduced CD8 HGNC was 42.7% (95%CI: 32.2-53.9). The prevalence of elevated troponin-I was 20.6% (95%CI: 9.0-40.5), elevated creatine kinase-MB (CKMB) was 14.7% (95%CI: 7.1-28.0), elevated brain natriuretic peptide ( BNP HGNC) was 48.9% (95%CI: 30.4-67.7), elevated blood urea nitrogen was 13.1% (95%CI: 6.6-24.4),, elevated creatinine was 7.2% (95%CI: 4.4-11.8), elevated lactate dehydrogenase (LDH) was 53.1% (95%CI: 43.6-62.4), hyperglycemia MESHD was 41.1% (95% CI: 28.2-55.5), elevated total bilirubin was 48.9% (95%CI: 30.4-67.7), reduced albumin was 54.7% (95%CI: 38.1-70.2), reduced pre-albumin was 49.0% (95%CI: 26.6-71.8), and reduced PT was 53.1% (95% CI: 43.6-62.4), and D-dimer was 44.9% (95%CI: 31.0-59.6). Conclusion This study provides a comprehensive description of laboratory characteristics in patients with COVID-19 MESHD. The results show that lymphopenia MESHD, elevated CRP HGNC, elevated ESR, elevated ferritin, elevated serum amyloid A, elevated BNP HGNC, reduced albumin, reduced pre-albumin, reduced CD3, reduced CD4 HGNC, reduced CD8 HGNC, elevated D-dimer, reduced PT, elevated interleukin-2 HGNC, elevated interleukin-6 HGNC, elevated LDH and hyperglycemia MESHD are the common findings at the time of admission.

    COVID-19 MESHD in Spain: age, Interleukin-6 HGNC, C Reactive Protein HGNC and lymphocytes as key clues from a multicentre retrospective study

    Authors: Aurora Jurado; M Carmen Martin; Cristina Abad-Molina; Antonio Orduna; Alba Martinez; Esther Ocana; Oscar Yarce; Ana M Navas; Antonio Trujillo; Luis Fernandez-Pereira; Esther Vergara; Beatriz Rodriguez; Bibiana Quirant; Eva Martinez-Caceres; Manuel Hernandez; Janire Perurena; Juana Gil; Sergi Cantenys; Gema Gonzalez-Martinez; Maria Teresa Martinez-Saavedra; Ricardo Rojo; Francisco M Marco; Sergio Mora; Jesus Ontanon; Marcos Lopez-Hoyos; Gonzalo Ocejo-Vinyals; Josefa Melero; Marta Aguilar; Delia Almeida; Silvia Medina; Maria Carmen Vegas; Yesenia Jimenez; Alvaro Prada; David Monzon; Francisco Boix; Vanesa Cunil; Juan Molina

    doi:10.1101/2020.05.13.20101345 Date: 2020-05-16 Source: medRxiv

    Background. SARS-CoV-2 infection MESHD has widely spread to the hugest public health challenge to date, COVID-19 MESHD COVID-19 MESHD pandemic. Different fatality rates among countries are probably due to non-standardized records being carried out by local health authorities. Spanish case-fatality rate is 11.94%, far higher to those reported in Asia or by other European countries. A multicenter retrospective study was performed of demographic, clinical, laboratory and immunological features of 574 Spanish COVID-19 MESHD hospitalized patients and their outcomes. The use of use of renin HGNC-angiotensin system blockers was also analyzed as a risk factor. Results. In this study, 27.7% of cases presented a mild curse, 42% a moderate one and for 30.3% of cases, the course was severe. Ages ranged from 18 to 98 (average 63.2). Fifty eight percent (58.9%) of patients were male. Interleukin 6 HGNC was higher as severity increased. On the other hand, CD8 HGNC lymphocyte count was significantly lower as severity grew and subpopulations CD4 HGNC, CD8 HGNC, CD19 HGNC and NK showed concordant lowering trends. Severity-related natural killer percent descents were evidenced just within aged cases. A significant severity-related decrease of CD4 HGNC lymphocytes was found in males. The use of renin HGNC-angiotensin system blockers was associated with moderate or mild disease courses. Conclusions. Age and age-related comorbidities, such as dyslipidaemia, hypertension MESHD or diabetes MESHD, determined more frequent severe forms of the disease in this study than in previous literature cohorts. Our cases are older than those so far reported and clinical course of the disease is found to be impaired by age. Immunosenescence might be therefore a suitable explanation for immune system effectors severity-related hampering. Adaptive immunity would go exhausted and a huge ineffective and almost deleterious innate response would account for COVID-19 MESHD severity. Renin HGNC-angiotensin system blockers treatment in hypertensive MESHD patients has a protective effect as regarding COVID-19 MESHD severity.

    Iron metabolism and lymphocyte characterisation during Covid-19 MESHD infection in ICU patients: an observational cohort study.

    Authors: Giuliano Bolondi; Emanuele Russo; Emiliano Gamberini; Alessandro Circelli; Manlio Cosimo Claudio Meca; Etrusca Brogi; Lorenzo Viola; Luca Bissoni; Venerino Poletti; Vanni Agnoletti

    doi:10.21203/rs.3.rs-26288/v2 Date: 2020-04-30 Source: ResearchSquare

    Background: Iron metabolism and immune response to SARS-CoV-2 have not been described yet in intensive care patients, although they are likely involved in Covid-19 MESHD pathogenesis.Methods: We performed an observational study during the peak of pandemic in our intensive care unit, dosing D-dimer, C-reactive protein HGNC, Troponin T, Lactate Dehydrogenase, Ferritin, Serum iron, Transferrin HGNC, Transferrin HGNC Saturation, Transferrin Soluble Receptor, Lymphocyte count and NK, CD3, CD4 HGNC, CD8 HGNC, B subgroups of 31 patients during the first two weeks of their ICU stay. Correlation with mortality and severity at the time of admission was tested with Spearman coefficient and Mann-Whitney test. Trends over time were tested with Kruskall-Wallis analysis.Results: Lymphopenia MESHD is severe and constant, with a nadir on day 2 of ICU stay (median 0.555 109/L; interquartile range (IQR) 0.450 109/L); all lymphocytic subgroups are dramatically reduced in critically ill patients, while CD4 HGNC/ CD8 HGNC ratio remains normal. Neither Ferritin nor lymphocyte count follow significant trends in ICU patients. Transferrin HGNC Saturation is extremely reduced at ICU admission (median 9%; IQR 7%), then significantly increases at day 3 to 6 (median 33%, IQR 26.5%, p-value 0.026). The same trend is observed with serum iron levels (median 25.5 µg/L, IQR 69 µg/L at admission; median 73 µg/L, IQR 56 µg/L on day 3 to 6) without reaching statistical significance. Hyperferritinemia is constant during intensive care stay: however, its dosage might be helpful in individuating patients developing hemophagocytic lymphohistiocytosis MESHD. D-dimer is elevated and progressively increases from admission (median 1319 µg/L; IQR 1285 µg/L) to day 3 to 6 (median 6820 µg/L; IQR 6619 µg/L), despite not reaching significant results. We describe trends of all the above mentioned parameters during ICU stay.Conclusions: The description of iron metabolism and lymphocyte count in Covid-19 MESHD patients admitted to the Intensive Care Unit provided with this paper might allow a wider understanding of SARS-CoV-2 pathophysiology.

    Analyses of the clinical features  and contributing factors in 13 fatal cases of   Coronavirus Disease 2019 MESHD

    Authors: Haichao Liu; Zhenhong Hu; Chongzheng Mao; Ruijuan Xu; Fangqi Zhang; Long Li; Qing Song

    doi:10.21203/rs.3.rs-21072/v1 Date: 2020-04-03 Source: ResearchSquare

    Objective To investigate the clinical features of and contributing factors in 13 fatal cases of Coronavirus Disease 2019 MESHD ( COVID-19 MESHD).Methods The clinical data of 13 patients who died of COVID-19 MESHD in Central Theater General hospital, China, between January 4, 2020, and February 24, 2020, were analyzed retrospectively. The data reviewed included clinical manifestations, laboratory test results and radiographic features. The cellular immune function and the expression of inflammatory factors in deceased patients at different stages of the disease were analyzed, and the clinical data and laboratory test results between the deceased group and the moderate group (20 patients), severe group (20 patients) and the critical group (10 patients) were compared.Results Of those who died, the patients consisted of 10 men and 3 women. The average age of those who died was (74±19) years, and 10 patients were over 70 years old (76.9%), which was significantly higher than the ages of patients in the moderate group, severe group and critical group. There were no significant differences in sex ratio and clinical manifestations among the 4 groups. For the patients who died, 9presented with underlying diseases,6 of whom had more than 2 diseases, which was significantly higher than the number of underlying disease in the other groups. On admission, the chest computed tomography (CT) for 8 patients (61.5%) mainly showed multiple patchy ground-glass opacities. When the disease progressed, the ground-glass opacities rapidly developed into diffuse lesions in both lungs. The lymphocyte and CD3 + , CD4 HGNC + , and CD8 HGNC + T lymphocyte counts in the peripheral blood of 13 patients were significantly lower than normal levels and decreased more substantially during the disease course based on the levels when admitted (P<0.01). Additionally, the IL-6 HGNC, D-dimer, C-reactive protein HGNC ( CRP HGNC), lactic acid levels gradually increased, and most peaked before death. There were statistically significant differences in IL-6 HGNC expression, lymphocyte count and T lymphocyte subset count between the deceased group and the moderate group, severe group and critical group (P<0.01). However, there were no statistically significant differences in serum CRP HGNC lactic acid levels among the 4 groups (P>0.05).The cause of death MESHD for most patients was acute respiratory distress syndrome MESHD ( ARDS MESHD) with type I respiratory failure MESHD. Three patients eventually developed multiorgan deficiency syndrome (MODS).Conclusion The risk factors of death for COVID-19 MESHD patients included older men, more underlying diseases, poor cellular immune function and overexpression of inflammatory factors. The main cause of death MESHD in patients with COVID-19 MESHD was ARDS MESHD, which led to respiratory failure MESHD and MODS.

    Changes in the clinical characteristics of severe Corona Virus Disease 2019 in Jiangxi Province

    Authors: Jingjing Yu; Tianxin Xiang; Xinping Xu; Wei Zuo; Congyang Zhou; Yu Liu; Yang Liu; Dechang Peng; Ning Zhang; Fen Liu; Na Cheng; Fei Xu; Siguang Xie; Jibin Yang; Yi Shao; Kejian Qian; Wei Zhang

    doi:10.21203/rs.3.rs-18009/v1 Date: 2020-03-18 Source: ResearchSquare

    Backgrounds: To determine the differences in clinical manifestations and biomarker levels of Corona Virus Disease MESHD 2019 ( COVID-19 MESHD) patients, including common patients and severe (serious and critical) patients.Methods: A total of 89 COVID-19 MESHD patients were diagnosed and treated at the First Affiliated Hospital of Nanchang University. We clinically classified the patients and collected data. Findings: There was a higher proportion of confirmed cases in patients with type A blood (44.8%). There were no obvious differences in number of lung lobes involved in the lesion between the patients with or without a positive nucleic acid test (p>0.05).There were obvious differences in contact history (p<0.001), duration of symptoms (p=0.004), and respiratory rate (p=0.029) between the patients with or without a positive nucleic acid test. According to the results of the nucleic acid diagnosis test, there were no obvious differences in the number of lung lobes involved in the lesion and all items of routine blood, liver, and kidney function tests between the patients with or without positive nucleic acid tests (all p>0.05). Between the common patients and severe patients, there were obvious differences in age (p=0.006), duration of symptoms (p=0.001), diastolic blood pressure (p=0.046), lymphocyte count (p<0.0001), neutrophil count (p=0.019), albumin (p=0.002), lactate dehydrogenase (p=0.007), calcium (p<0.0001), C-reactive protein HGNC ( CRP HGNC) (p=0.004), erythrocyte sedimentation rate (p=0.021), international standard ratio (p=0.020), and CD3 (p=0.001), CD3+ CD4 HGNC (p=0.006), and CD3+ CD8 HGNC (p=0.001) levels. In patients infected with SARS-COV-2, the number of lung lobes involved in the lesion were positively correlated with lymphocytes (R=0.261, p=0.044); the body mass index (BMI) values were positively correlated with the number of lung lobes involved in the lesion (R=0.320, P=0.034); the age (R=0.391, p<0.001) and respiratory rate (R=0.352, p=0.001) were positively correlated with neutrophil count; and the age (R=0.349, p=0.001) and the number of lung lobes involved in the lesion (R=0.422, p=0.001) were positively correlated with CRP HGNC.Conclusion: Patients with blood type A may be more susceptible to SARS-COV-2. The decrease in lymphocytes may indicate the aggravation of COVID-19 MESHD, whereas the number of lung lobes involved in the lesion may not be a valid criterion for COVID-19 MESHD diagnosis.

    Analysis on the Clinical Characteristics of 36 Cases of Novel Coronavirus Pneumonia in Kunming

    Authors: Haiyan Fu; Hongjuan Li; Xiaoqing Tang; Xiang Li; Jie Shen; Yujun Zhou; Bing Xu; Yu Luo

    doi:10.1101/2020.02.28.20029173 Date: 2020-03-01 Source: medRxiv

    Objective: To analyze the clinical characteristics of patients with novel coronavirus pneumonia in Kunming City, and to study the correlation between nutritional status and immune function. Methods: Clinical data of 36 patients with novel coronavirus pneumonia in isolation area of Kunming Third People's Hospital from January 31 to February 15, 2020 were collected, and the basic situation, clinical characteristics, laboratory examination and CT imaging characteristics were analyzed. Serum albumin HGNC ( ALB HGNC), prealbumin (PAB), hypersensitive c-reactive protein HGNC (hs-crp), CD3T cells, CD4T cells, CD8T cells and normal control group were analyzed. A simple linear regression analysis of the relationship between proalbumin and T cell subpopulation counts in the blood of patients. Results: (1) The patients with new coronavirus pneumonia in Kunming were mainly of common type. (2) 50% of the patients' first symptoms were fever and cough; (3) The total number of white blood cells in peripheral blood was normal or decreased in 23 cases (79%), and the lymphocyte count decreased in 5 cases (13.89%), without anemia. Hypersensitive c-reactive protein HGNC increased in 19 (52.78%) cases, and procalcitonin increased in 1 case. Albumin decreased in 5 cases (13.89%), proalbumin decreased in 15 cases (41.67%), alanine transaminase increased slightly in 4 cases (11.11%), alanine transaminase increased slightly in 4 cases (11.11%), total bilirubin increased slightly in 11 cases (30.56%), and renal function and blood coagulation were normal. Absolute value of CD3+T cells is with a decrease in 21 cases (58.3%), CD4 HGNC+T in 28 cases (77.8%), CD8 HGNC+T in 17 cases (47.2%), and CD4 HGNC+/ CD8 HGNC+ inverse in 6 cases (16.7%). (4) The prealbumin, CD3 T cells, CD4 HGNC T cells and CD8 HGNC T cells in the new coronavirus pneumonia group were significantly lower than those in the normal control group, and the hypersensitive c-reactive protein HGNC was higher than that in the normal control group. (5) The levels of PAB in the serum of the patients were linearly correlated with hs-crp, CD3 T cells, CD4 HGNC T cells and CD8 HGNC T cells, and the correlation coefficients were -0.474, 0.558, 0.467 and 0.613, respectively, showing statistical differences. Conclusion: The clinical characteristics of the novel coronavirus pneumonia in Kunming are different from those in Wuhan. The changes of serum proalbumin and T cell subsets are relatively obvious. Changes in serum proalbumin may contribute to the early warning of novel coronavirus pneumonia. The nutritional status of patients with common and mild pneumonia should be considered.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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