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SARS-CoV-2 proteins

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    The potential role of IL-6 HGNC in monitoring coronavirus disease 2019 MESHD.

    Authors: Tao Liu; Jieying Zhang; Yuhui Yang; Hong Ma; Zhengyu Li; Jiaoyue Zhang; Ji Cheng; Xiaoyun Zhang; Yanxia Zhao; Zihan Xia; Liling Zhang; Gang Wu; Jianhua Yi

    doi:10.1101/2020.03.01.20029769 Date: 2020-03-06 Source: medRxiv

    Abstract. Background: The outbreak of coronavirus disease 2019 MESHD ( COVID-19 MESHD) in Wuhan City, China spreads rapidly since December, 2019. Most patients show mild symptoms, but some of them develop into severe disease. There is currently no specific medication. The purpose of this study is to to explore changes of markers in peripheral blood of severe COVID-19 MESHD patients, which may be of value in disease monitoring. Methods Clinical data of patients with nonsevere and severe type COVID-19 MESHD diagnosed by laboratory test in our institution were collected. The relationship between peripheral blood cells and cytokines, clinical manifestation and outcome was analyzed. Results A total of 69 severe type COVID-19 MESHD patients were included. On admission, the median age of severe cases was 56-year old, with 52.17% female patient. The most common symptoms were fever MESHD (79.72%), cough (63.77%), shortness of breath MESHD (57.97%) and fatigue MESHD (50.72%). Diarrhea MESHD is less common. The most common comorbidity is hypertension MESHD. Upon admission, the proportion of bilateral pulmonary involvement and interstitial abnormalities MESHD evidenced by chest computed tomography (CT) imaging in severe cases was 60.87% and 27.54%, respectively. Compared with patients with nonsevere disease, those with severe disease showed obvious lymphocytopenia MESHD. Elevated level of lactate dehydrogenase (LDH), C-reactive protein (CRP) HGNC, ferritin and D-dimer was found in most cases. Two patients (2.9%) needed transfer to the intensive care unit. Baseline immunological parameters and most of the inflammatory parameters were basically within the normal range. However, baseline interleukin-6 HGNC ( IL-6 HGNC) was significantly increased in severe type, which was closely related to the maximal body temperature during hospitalization and to CT findings. Baseline IL-6 HGNC was also significantly related to the increase of baseline level of CRP HGNC, LDH, ferritin and D-dimer. The increase of baseline IL-6 HGNC level suggests that it may positively correlate with the severity of COVID-19 MESHD. Among the 30 severe type patients whose IL-6 HGNC was assessed before and after treatment, significant decrease in IL-6 HGNC and improved CT assessment was found in 25 patients after treatment. Whereas the IL-6 HGNC level was further increased in 3 cases, which was closely related to disease progression. It is suggested that IL-6 HGNC may be used as a marker for disease monitoring in severe COVID-19 MESHD patients. Conclusions On admission, the baseline level of IL-6 HGNC, CRP HGNC, LDH and ferritin was closely related to the severity of COVID-19 MESHD, and the elevated IL-6 HGNC was significantly related to the clinical manifestation of severe type patients. The decrease of IL-6 HGNC was closely related to treatment effectiveness, while the increase of IL-6 HGNC indicated disease exacerbation. Collectively, the dynamic change of IL-6 HGNC level can be used as a marker for disease monitoring in patients with severe COVID-19 MESHD.

    Clinical characteristics of 25 death cases infected with COVID-19 MESHD pneumonia: a retrospective review of medical records in a single medical center, Wuhan, China

    Authors: Xun Li; Luwen Wang; Shaonan Yan; Fan Yang; Longkui Xiang; Jiling Zhu; Bo Shen; Zuojiong Gong

    doi:10.1101/2020.02.19.20025239 Date: 2020-02-25 Source: medRxiv

    Summary Background The pneumonia MESHD caused by the 2019 novel coronavirus (SARS-CoV-2) is a highly infectious disease MESHD, which was occurred in Wuhan, Hubei Province, China in December 2019. As of February 13, 2020, a total of 59883 cases of COVID-19 MESHD in China have been confirmed and 1368 patients have died from the disease. However, the clinical characteristics of the dyed patients were still not clearly clarified. This study aims to summarize the clinical characteristics of death cases with COVID-19 MESHD and to identify critically ill patients of COVID-19 MESHD early and reduce their mortality. Methods The clinical records, laboratory findings and radiologic assessments included chest X-ray or computed tomography were extracted from electronic medical records of 25 died patients with COVID-19 MESHD in Renmin Hospital of Wuhan University from Jan 14 to Feb 13, 2020. Two experienced clinicians reviewed and abstracted the data. Findings The mean age of the dead was 71.48 years, the average course of the disease was 10.56 days, all patients eventually died of respiratory failure MESHD. All of those who died had underlying diseases, the most common of which was hypertension MESHD (16/25, 64%), followed by diabetes MESHD (10/25, 40%), heart diseases MESHD (8/25, 32%), kidney diseases MESHD (5/25, 20%), cerebral infarction MESHD (4/25, 16%), chronic obstructive pulmonary disease MESHD ( COPD MESHD, 2/25, 8%), malignant tumors MESHD (2/25, 8%) and acute pancreatitis MESHD (1/25, 4%). The most common organ damage outside the lungs was the heart, followed by kidney and liver. In the patients' last examination before death MESHD, white blood cell and neutrophil counts were elevated in 17 patients (17/25, 68%) and 18 patients (18/25, 72%), lymphocyte counts were decreased in 22 patients (22/25, 88%). Most patients' PCT HGNC, CRP HGNC and SAA levels were elevated, the percentages were 90.5% (19/21), 85% (19/20) and 100% (21/21) respectively. The levels of the last test of neutrophils (15/16, 93.8%), PCT HGNC (11/11, 100%), CRP HGNC (11/13, 84.6%), cTnI HGNC (8/9, 88.9%), D-Dimer (11/12, 91.6%) and LDH (9/9, 100%) were increased as compared to the first test, while the levels of lymphocytes were decreased (14/16, 87.5%). Interpretation The age and underlying diseases ( hypertension MESHD, diabetes MESHD, etc.) were the most important risk factors for death of COVID-19 MESHD pneumonia MESHD. Bacterial infections may play an important role in promoting the death of patients. Malnutrition MESHD was common to severe patients. Multiple organ dysfunction can be observed, the most common organ damage was lung, followed by heart, kidney and liver. The rising of neutrophils, SAA, PCT HGNC, CRP HGNC, cTnI HGNC, D-Dimer and LDH levels can be used as indicators of disease progression, as well as the decline of lymphocytes counts.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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