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HGNC Genes

SARS-CoV-2 proteins

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    The Prognostic Value of Myocardial Injury MESHD in COVID-19 MESHD Patients and Associated Characteristics

    Authors: jian he; Bicheng Zhang; Quan Zhou; Wenjing Yang; Jing Xu; Tingting Liu; Haijun Zhang; Zhiyong Wu; Dong Li; Qing Zhou; Jie Yan; Cuizhen Zhang; Robert G. Weiss; Guanshu Liu; Zhongzhao Teng; Arlene Sirajuddin; Haiyan Qian; Shihua Zhao; Andrew E. Arai; Minjie Lu; Xiaoyang Zhou

    doi:10.21203/rs.3.rs-251810/v1 Date: 2021-02-17 Source: ResearchSquare

    Background: Since December 2019, Coronavirus disease 2019 MESHD ( COVID-19 MESHD) has emerged as an international pandemic. COVID-19 MESHD patients with myocardial injury MESHD might need special attention. However, understanding on this aspect remains unclear. This study aimed to illustrate clinical characteristics and the prognostic value of myocardial injury MESHD to COVID-19 MESHD patients. Methods: This retrospective, single-center study finally included 304 hospitalized COVID-19 MESHD cases confirmed by real-time RT-PCR from January 11 to March 25, 2020. Myocardial injury MESHD was determined by serum high-sensitivity troponin I (Hs-TnI). The primary endpoint was COVID-19 MESHD associated mortality. Results: Of 304 COVID-19 MESHD patients (median age, 65 years; 52.6% males), 88 patients (27.3%) died (61 patients with myocardial injury MESHD, 27 patients without myocardial injury MESHD on admission). COVID-19 MESHD patients with myocardial injury MESHD had more comorbidities ( hypertension MESHD, chronic obstructive pulmonary disease MESHD, cardiovascular disease MESHD, and cerebrovascular disease MESHD); lower lymphocyte counts, higher C-reactive protein HGNC ( CRP HGNC, median, 84.9 vs 28.5 mg/L, p<0.001), procalcitonin levels (median, 0.29 vs 0.06 ng/ml, p<0.001), inflammatory and immune response markers; more frequent need for noninvasive ventilation, invasive mechanical ventilation; and was associated with higher mortality incidence (hazard ratio, HR=7.02, 95% confidence interval, CI, 4.45-11.08, p<0.001) than those without myocardial injury MESHD. Myocardial injury MESHD (HR=4.55, 95% CI, 2.49-8.31, p<0.001), senior age, CRP HGNC levels, and novel coronavirus pneumonia MESHD ( NCP PROTEIN) types on admission were independent predictors to mortality in COVID-19 MESHD patients. Conclusions: COVID patients with myocardial injury MESHD on admission is associated with more severe clinical presentation and biomarkers. Myocardial injury MESHD and higher HsTNI are both strongest independent predictors to COVID related mortality after adjusting confounding factors. In addition, senior age, CRP HGNC levels and NCP PROTEIN types are also associated with mortality. Trial registration: Not applicable.

    The kidnapping of mitochondrial function associated to the SARS-CoV-2 infection MESHD

    Authors: Elizabeth Soria-Castro; María Elena Soto; Verónica; Gustavo Rojas; Mario Perezpeña-Diazconti; Sergio A Críales-Vera; Linaloe Manzano Pech; Israel Pérez-Torres

    doi:10.21203/rs.3.rs-137853/v1 Date: 2020-12-29 Source: ResearchSquare

    Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection leads to multiorganic failure MESHD associated with a cytokine storm and septic shock MESHD. The virus evades the mitochondrial production of interferons through its N protein PROTEIN. From that moment on, SARS-CoV-2 hijacks MESHD the functions of this organelle. The aim of this study was to show how the virus kidnaps the mitochondrial machinery for its benefit and survival, altering serum parameters and leading to nitrosative stress (NSS). In a prospective cohort of 15 postmortem patients who died from COVID-19 MESHD, six markers of mitochondrial function; COX II, COX IV HGNC, MnSOD HGNC, nitrotyrosine, Bcl-2 HGNC and caspase-9 HGNC were analyzed by the immune colloidal gold technique in samples from the lung, heart, kidney and liver. Biometric laboratory results from these patients showed alterations in hemoglobin, platelets, creatinine, urea nitrogen, glucose, C-reactive protein HGNC, albumin, D-dimer, ferritin, fibrinogen HGNC, Ca2+, K+, lactate and troponin. These changes were associated with alterations of the mitochondrial structure and function. The multiorganic dysfunction MESHD present in COVID-19 MESHD patients may be caused in part by damage to the mitochondria that results in an inflammatory state that contributes to the elevation of NSS. NSS activates the sepsis MESHD cascade and contributes to the increased mortality in COVID-19 MESHD patients.

    Expansion of SARS-CoV-2-specific Antibody-secreting Cells and Generation of Neutralizing Antibodies in Hospitalized COVID-19 MESHD Patients

    Authors: Renata Varnaitė; Marina García; Hedvig Glans; Kimia T Maleki; John Tyler Sandberg; Janne Tynell; Wanda Christ; Nina Lagerqvist; Hilmir Asgeirsson; Hans-Gustaf Ljunggren; Gustaf Ahlén; Lars Frelin; Matti Sällberg; Kim Blom; Jonas Klingström; Sara Gredmark-Russ

    doi:10.1101/2020.05.28.118729 Date: 2020-05-29 Source: bioRxiv

    Coronavirus disease 2019 MESHD ( COVID-19 MESHD), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in late 2019 and has since become a global pandemic. Pathogen-specific antibodies are typically a major predictor of protective immunity, yet B cell and antibody responses during COVID-19 MESHD are not fully understood. Here, we analyzed antibody-secreting cell (ASC) and antibody responses in twenty hospitalized COVID-19 MESHD patients. The patients exhibited typical symptoms of COVID-19 MESHD, and presented with reduced lymphocyte numbers and increased T cell and B cell activation. Importantly, we detected an expansion of SARS-CoV-2 nucleocapsid protein PROTEIN-specific ASCs in all twenty COVID-19 MESHD patients using a multicolor FluoroSpot assay. Out of the 20 patients, 16 had developed SARS-CoV-2-neutralizing antibodies by the time of inclusion in the study. SARS-CoV-2-specific IgA, IgG and IgM antibody levels positively correlated with SARS-CoV-2-neutralizing antibody titers, suggesting that SARS-CoV-2-specific antibody levels may reflect the titers of neutralizing antibodies in COVID-19 MESHD patients during the acute phase of infection. Lastly, we showed that interleukin 6 HGNC ( IL-6 HGNC) and C-reactive protein HGNC ( CRP HGNC) concentrations were higher in serum of patients who were hospitalized for longer, supporting the recent observations that IL-6 HGNC and CRP HGNC could be used to predict COVID-19 MESHD severity. Altogether, this study constitutes a detailed description of clinical and immunological parameters in twenty COVID-19 MESHD patients, with a focus on B cell and antibody responses, and provides tools to study immune responses to SARS-CoV-2 infection MESHD and vaccination.

    Artificial intelligence-based CT metrics in relation with clinical outcome of COVID-19 MESHD in young and middle-aged adults

    Authors: Sihui Zeng; Weihong Liu; Xudong Yu; Yanli Li; Jiao Gao; Jiawei Li; Hanhui Li; Liang Mao; Chuanmiao Xie; Jianye Liang

    doi:10.21203/rs.3.rs-24561/v1 Date: 2020-04-22 Source: ResearchSquare

    Purposes: Currently, most researchers mainly analyzed COVID-19 MESHD pneumonia visually MESHD or qualitatively, probably somewhat time-consuming and not precise enough. This study aimed to excavate more information, such as differences in distribution, density, and severity of pneumonia lesions MESHD between males and females in a specific age group using artificial intelligence (AI)-based CT metrics. Besides, these metrics were incorporated into a clinical regression model to predict the short-term outcome.Methods: The clinical, laboratory information and a series of HRCT images from 49 patients, aged from 20 to 50 years and confirmed with COVID-19 MESHD, were collected. The volumes and percentages of infection (POI) among bilateral lungs and each bronchopulmonary segment were extracted using uAI-Discover- NCP PROTEIN software (version R001). The POI in three HU ranges, (i.e. <-300, -300~49 and ≥50 HU representing ground-glass opacity (GGO), mixed opacity and consolidation), were also extracted. Hospital stay was predicted with several POIs after adjusting days from illness onset to admission, leucocytes, lymphocytes, c-reactive protein HGNC, age and gender using a multiple linear regression model.Results: Right lower lobes had the highest POI, followed by left lower lobes, right upper lobes, middle lobes MESHD and left upper lobes. The distributions in lung lobes and segments were different between the sexes. Men had a higher total POI and GGO of the lungs, but less consolidation than women in initial CT (all p<0.05). The total POI, percentage of consolidation on initial CT and changed POI were positively correlated with hospital stay in the model.Conclusion: Both men and women had characteristic distributions in lung lobes MESHD and bronchopulmonary segments. AI-based CT quantitative metrics can provide more precise information regarding lesion distribution and severity to predict clinical outcome.

    Risk factors for severe corona virus disease 2019 ( COVID-19 MESHD) patients : a systematic review and meta analysis

    Authors: Lizhen Xu; mao yaqian; Gang Chen

    doi:10.1101/2020.03.30.20047415 Date: 2020-04-01 Source: medRxiv

    Importance: With the increasing number of infections for COVID-19 MESHD, the global health resources are deficient. At present, we don't have specific medicines or vaccines against novel coronavirus pneumonia MESHD ( NCP PROTEIN) and our assessment of risk factors for patients with severe pneumonia MESHD was limited. In order to maximize the use of limited medical resources, we should distinguish between mild and severe patients as early as possible. Objective: To systematically review the evidence of risk factors for severe corona virus disease MESHD 2019 ( COVID-19 MESHD) patients. Evidence Review: We conducted a comprehensive search for primary literature in both Chinese and English electronic bibliographic data bases including China National Knowledge Infrastructure (CNKI), Wanfang, Weipu, Chinese Biomedicine Literature Database (CBM-SinoMed), MEDLINE (via PubMed), EMBASE, Cochrane Central Register, and Web of science. The American agency for health research and quality (AHRQ) tool were used for assessing risk of bias. Mata-analysis was undertaken using STATA version 15.0. Results: 20 articles (N=4062 participants) were eligible for this systematic review and meta-analysis. First in this review and meta-analysis, we found that elderly male patients with a high body mass index, high breathing rate and a combination of underlying diseases (such as hypertension MESHD, diabetes MESHD, cardiovascular disease MESHD, and chronic obstructive pulmonary disease MESHD) were more likely to develop into critically ill MESHD patients. second, compared with ordinary patients, severe patients had more significant symptom such as fever MESHD and dyspnea MESHD. Besides, the laboratory test results of severe patients had more abnormal than non-severe patients, such as the elevated levels of white-cell counts, liver enzymes, lactate dehydrogenase, creatine kinase, c-reactive protein HGNC and procalcitonin, etc, while the decreased levels of lymphocytes and albumin, etc. Interpretation: This is the first systematic review investigating the risk factors for severe corona virus disease MESHD 2019 ( COVID-19 MESHD) patients. The findings are presented and discussed by different clinical characteristics. Therefore, our review may provide guidance for clinical decision-making and optimizes resource allocation.

    Acute Myocardial Injury of Patients with Coronavirus Disease 2019 MESHD

    Authors: Huayan Xu; Keke Hou; Hong Xu; Zhenlin Li; Huizhu Chen; Na Zhang; Rong Xu; Hang Fu; Ran Sun; Lingyi Wen; Linjun Xie; Hui Liu; Kun Zhang; Joseph B Selvanayagam; Chuan Fu; Shihua Zhao; Zhigang Yang; Ming Yang; Yingkun Guo

    doi:10.1101/2020.03.05.20031591 Date: 2020-03-08 Source: medRxiv

    Background: Since the outbreak of the Coronavirus Disease 2019 MESHD ( COVID-19 MESHD) in China, respiratory manifestations of the disease have been observed. However, as a fatal comorbidity, acute myocardial injury MESHD ( AMI MESHD) in COVID-19 MESHD patients has not been previously investigated in detail. We investigated the clinical characteristics of COVID-19 MESHD patients with AMI MESHD and determined the risk factors for AMI MESHD in them. Methods: We analyzed data from 53 consecutive laboratory-confirmed and hospitalized COVID-19 MESHD patients (28 men, 25 women; age, 19-81 years). We collected information on epidemiological and demographic characteristics, clinical features, routine laboratory tests (including cardiac injury MESHD biomarkers), echocardiography, electrocardiography, imaging findings, management methods, and clinical outcomes. Results: Cardiac complications were found in 42 of the 53 (79.25%) patients: tachycardia MESHD (n=15), electrocardiography abnormities (n=11), diastolic dysfunction MESHD (n=20), elevated myocardial enzymes (n=30), and AMI MESHD (n=6). All the six AMI MESHD patients were aged >60 years; five of them had two or more underlying comorbidities ( hypertension MESHD, diabetes MESHD, cardiovascular diseases MESHD, and chronic obstructive pulmonary disease MESHD). Novel coronavirus pneumonia MESHD ( NCP PROTEIN) severity was higher in the AMI MESHD patients than in patients with non-definite AMI MESHD (p<0.001). All the AMI MESHD patients required care in intensive care unit; of them, three died, two remain hospitalized. Multivariate analyses showed that C-reactive protein HGNC ( CRP HGNC) levels, NCP PROTEIN severity, and underlying comorbidities were the risk factors for cardiac abnormalities MESHD in COVID-19 MESHD patients. Conclusions: Cardiac complications MESHD are common in COVID-19 MESHD patients. Elevated CRP HGNC levels, underlying comorbidities, and NCP PROTEIN severity are the main risk factors for cardiac complications in COVID-19 MESHD patients.

    Epidemiological and Clinical Characteristics of 17 Hospitalized Patients with 2019 Novel Coronavirus Infection MESHDs Outside Wuhan, China

    Authors: Jie Li; Shilin Li; Yurui Cai; Qin Liu; Xue Li; Zhaoping Zeng; Yanpeng Chu; Fangcheng Zhu; Fanxin Zeng

    doi:10.1101/2020.02.11.20022053 Date: 2020-02-12 Source: medRxiv

    An increasing number of cases of novel coronavirus pneumonia (NCP) infected MESHD NCP PROTEIN) infected with 2019-nCoV have been identified in Wuhan and other cities in China, since December 2019. We analyzed data on the 17 confirmed cases in Dazhou to provide the epidemiologic characteristics of NCP PROTEIN outside Wuhan. Among them, 12 patients were still quarantined in the hospital, 5 patients were discharged NCP PROTEIN patients according to the national standards. Compared with non-discharged NCP PROTEIN patients, the discharged NCP PROTEIN patients had younger ages. Moreover, discharged NCP PROTEIN patients had higher heart rate, lymphocytes levels and monocytes levels than non-discharged NCP PROTEIN patients on admission to the hospital. Notably, all of 17 patients had abnormal increased C-reactive protein HGNC levels, and 16 patients had abnormal computed tomography images. This study provided some information that younger age, higher lymphocytes levels and monocytes levels at the diagnoses of 2019-nCoV may contributed to faster recovery and better therapeutic outcome.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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