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SARS-CoV-2 proteins

ProteinS1 (1)


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    Clinical Correlates of Early IgG Response in Patients with Mild COVID-19 MESHD

    Authors: Asa Kessler; Ariel Kenig; Henny Azmanov; Ram Gelman; Noa Hurvitz; Itay Perets; Esther Oiknine-Djian; Tali Bdolah-Abram; Orly Zelig; Zeev Rotstein; Yaron Ilan; Dana G. Wolf

    doi:10.21203/rs.3.rs-56853/v1 Date: 2020-08-10 Source: ResearchSquare

    Background: We determined the temporal pattern of early SARS-CoV-2 IgG response in patients with mild COVID-19 MESHD, and sought to identify predictive clinical and laboratory features. Methods:  Serum samples were prospectively obtained from 111 convalescent COVID-19 MESHD patients, staying in dedicated Isolation–hotels, and tested for the presence of SARS-CoV-2 IgG by anti- S1 protein PROTEIN ELISA.Results: SARS-CoV-2 IgG was detected in 78 (70.3%) patients tested within the first month from diagnosis. While highly variable between patients, the rate of antibody detection generally increased with time, from 47.1% to 93.8% at the first and fourth weeks from diagnosis, respectively, with the largest shift observed between the second and third week. Notably, the presence of more profound symptoms at presentation, namely, fever MESHD and chills, positively and independently correlated with early antibody response. IgG-positive patients had higher ferritin levels (p=0.039). Older age (p<0.001) and increased CRP HGNC levels (p=0.001) were associated with higher SARS-CoV-2 IgG levels. Conclusions: The identified temporal pattern along with the correlation between inflammation MESHD-related clinical and laboratory parameters and early IgG response in patients with mild COVID-19 MESHD, could provide a basis for better prediction and understating of the immune response to SARS-CoV-2, and inform therapeutic donor-plasma selection.  

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MeSH Disease
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SARS-CoV-2 Proteins


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