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MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

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    Serum S100B HGNC protein as a marker of severity in Covid-19 MESHD patients

    Authors: Antonio Aceti; Lory Marika Margarucci; Elena Scaramucci; Massimiliano Orsini; Gerardo Salerno; Gabriele Di Sante; Gianluca Gianfranceschi; Rosa Di Liddo; Federica Valeriani; Francesco Ria; Maurizio Simmaco; Pier Paolo Parnigotto; Matteo Vitali; Vincenzo Romano Spica; Fabrizio Michetti

    doi:10.21203/rs.3.rs-50341/v1 Date: 2020-07-28 Source: ResearchSquare

    SARS-CoV-2 infection MESHD shows a wide-ranging clinical severity, requiring prognostic markers. We focused on S100B HGNC, a calcium-binding protein present in biological fluids, being a reliable biomarker in disorders having inflammatory processes as common basis and RAGE HGNC as main receptor. Since Covid-19 MESHD is characterized by a potent inflammatory response also involving RAGE HGNC, we tested if S100B HGNC serum levels were related to disease severity.Serum samples (n=74) were collected from hospitalized SARS-CoV-2 positive patients admitted to Covid center. Illness severity was established by admission clinical criteria and Covid risk score. Treatment protocols followed WHO guidelines available at the time. Circulating S100B HGNC was determined by ELISA assay. Statistical analysis used Pearson’s χ2 test, t-Test, and ANOVA, ANCOVA, Linear Regression. S100B HGNC was detected in serum from Covid-19 MESHD patients, significantly correlating with disease severity as shown both by the level of intensity of care (p<0.006) as well by the value of Covid score (Multiple R-squared: 0.3751); the correlation between Covid-Score and S100B HGNC was 0.61 (p<0.01). S100B HGNC concentration was associated with inflammation MESHD markers (Ferritin, C-Reactive Protein HGNC, Procalcitonin), and organ damage markers ( Alanine Aminotransferase HGNC, Creatinine). Serum S100B HGNC plays a role in Covid-19 MESHD and can represent a prognostic marker in Sars- CoV-2 infected MESHD patients.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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