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HGNC Genes

SARS-CoV-2 proteins

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    The Inflammatory Markers of Multisystem Inflammatory Syndrome MESHD in children ( MIS HGNC-C) and Adolescents During the COVID-19 Pandemic MESHD: A Meta-Analysis

    Authors: Yan Zhao; Li-juan Yin; Jenil Patel; Lei Tang; Ying Huang

    doi:10.21203/rs.3.rs-127768/v1 Date: 2020-12-13 Source: ResearchSquare

    As per the indicated need in literature, we conducted a systematic review and meta-analysis to characterize inflammatory markers of MIS HGNC-C patients with COVID-19 MESHD, Kawasaki disease MESHD ( KD MESHD), and coronary artery abnormalities MESHD. We searched nine databases for studies on inflammatory markers of MIS HGNC-C. After quality check, data were pooled using a fixed- or random-effects model. Inflammatory markers included white blood cell count (WBC) or leukocytes, absolute lymphocyte count ( ALC HGNC), absolute neutrophil count (ANC), platelet count (PLT), C-reactive protein HGNC ( CRP HGNC), procalcitonin (PCT), ferritin, D-dimer, lactate dehydrogenase (LDH), fibrinogen HGNC and erythrocyte sedimentation rate (ESR) for comparisons by severity and age. Twenty studies with 2,990 participants yielded 684 MIS HGNC-C patients. Compared to non-severe COVID-19 MESHD patients, MIS-C MESHD MIS-C HGNC patients had lower ALC HGNC ALC MESHD and higher ANC, CRP HGNC and D-dimer levels. Compared to severe COVID-19 MESHD patients, MIS-C MESHD MIS-C HGNC patients had lower LDH MESHD and PLT counts and higher ESR levels. Compared to KD MESHD patients, MIS-C MESHD MIS-C HGNC patients had lower ALC MESHD ALC HGNC and PLT, and higher CRP HGNC and ferritin levels. Severe MIS HGNC-C patients had higher levels of WBC, CRP HGNC, D-dimer and ferritin. For MIS HGNC-C, younger children had lower CRP HGNC and ferritin levels than medium-aged/older children. Measurement of inflammatory markers might assist clinicians in accurate evaluation and diagnosis of MIS HGNC-C and the associated disorders.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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