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HGNC Genes

SARS-CoV-2 proteins

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    A systematic review on Multisystem Inflammatory Syndrome in Children ( MIS HGNC-C) with COVID-19 MESHD: Development of a scoring system for clinical diagnosis

    Authors: Dr.Suchitra Vishwambhar Surve; Ms. Shaini Joseph; Dr. Rahul K Gajbhiye; Smita D Mahale; Dr. Deepak N Modi

    doi:10.1101/2021.04.23.21255879 Date: 2021-04-25 Source: medRxiv

    Background There is growing evidence of Multisystem Inflammatory Syndrome MESHD in Children ( MIS HGNC-C) resembling Kawasaki disease in children infected with SARS-CoV-2. The review was undertaken to evaluate the case definition, the spectrum of clinical presentations and current management practices in children with COVID-19 MESHD presenting with or without MIS HGNC-C. Methods The individual patient data from 119 studies accounting for 333 children were analyzed. We devised a scoring system as per WHO criteria to classify the patients as MIS HGNC-C or without MIS HGNC-C. A score of 3 was given for the presence of fever MESHD (>24h) and a score of 1 for lab-confirmed diagnosis of SARS-CoV-2. Additionally, a score of 1 was given for a) rash MESHD or conjunctivitis MESHD or muco-cutaneous inflammation MESHD signs, b) hypotension MESHD or shock, c) diarrhea MESHD, vomiting MESHD or abdominal pain MESHD, d) features of myocardial dysfunction MESHD as determined by abnormal eco-cardiography or elevated Troponin or N-terminal pro b-type natriuretic peptide (NT-proBNP), e) evidence of coagulopathy MESHD as evidenced by elevated levels of prothrombin time PT, partial thromboplastin time PTT or D-dimer, f) laboratory evidence of inflammation MESHD as determined by elevated erythrocyte sedimentation rate (ESR) or C-reactive protein HGNC ( CRP HGNC) or procalcitonin. A negative score of (-3) was given when there was a diagnosis of sepsis MESHD, staphylococcal or streptococcal shock syndrome MESHD. Based on these criteria, a minimum score of 6 was essential to classify the child as MIS HGNC-C. Results Based on this score, 18% (52/289) of cases were identified to be MIS HGNC-C. A greater proportion of children with MIS HGNC-C had cardiac involvement ( MIS HGNC-C 80% vs Non- MIS HGNC-C 20%) and gastrointestinal involvement MESHD ( MIS HGNC-C 71% vs Non- MIS HGNC-C 12%). Lymphopenia MESHD was commonly reported in MIS-C ( MIS HGNC-C 54.2% vs Non- MIS HGNC-C 29.7%). In addition to routine inflammatory markers, significamtly greater proportion of children with MIS-C had elevated Ferritin, LDH, Fibrinogen HGNC and IL-6 HGNC. Children with MIS HGNC-C were less likely to have respiratory symptoms like cough ( MIS HGNC-C 25% vs Non- MIS HGNC-C 75%) and rhinorrhea MESHD ( MIS HGNC-C 4% vs Non- MIS HGNC-C 22.8%). A greater proportion of children with MIS HGNC-C required intensive care and aggressive treatment; and mortality rates were also higher in MIS-C group ( MIS HGNC-C 10% vs Non- MIS HGNC-C 1%). Conclusion The children with COVID-19 MESHD having cardiac and/or gastrointestinal involvement MESHD are more likely to develop MIS HGNC-C. The children with MIS HGNC-C have higher mortality rates. The scoring system developed herein will aid clinicians in patient diagnosis and timely management.

    The Inflammatory Markers of Multisystem Inflammatory Syndrome MESHD in children ( MIS HGNC-C) and Adolescents During the COVID-19 Pandemic MESHD: A Meta-Analysis

    Authors: Yan Zhao; Li-juan Yin; Jenil Patel; Lei Tang; Ying Huang

    doi:10.21203/rs.3.rs-127768/v1 Date: 2020-12-13 Source: ResearchSquare

    As per the indicated need in literature, we conducted a systematic review and meta-analysis to characterize inflammatory markers of MIS HGNC-C patients with COVID-19 MESHD, Kawasaki disease MESHD ( KD MESHD), and coronary artery abnormalities MESHD. We searched nine databases for studies on inflammatory markers of MIS HGNC-C. After quality check, data were pooled using a fixed- or random-effects model. Inflammatory markers included white blood cell count (WBC) or leukocytes, absolute lymphocyte count ( ALC HGNC), absolute neutrophil count (ANC), platelet count (PLT), C-reactive protein HGNC ( CRP HGNC), procalcitonin (PCT), ferritin, D-dimer, lactate dehydrogenase (LDH), fibrinogen HGNC and erythrocyte sedimentation rate (ESR) for comparisons by severity and age. Twenty studies with 2,990 participants yielded 684 MIS HGNC-C patients. Compared to non-severe COVID-19 MESHD patients, MIS-C MESHD MIS-C HGNC patients had lower ALC HGNC ALC MESHD and higher ANC, CRP HGNC and D-dimer levels. Compared to severe COVID-19 MESHD patients, MIS-C MESHD MIS-C HGNC patients had lower LDH MESHD and PLT counts and higher ESR levels. Compared to KD MESHD patients, MIS-C MESHD MIS-C HGNC patients had lower ALC MESHD ALC HGNC and PLT, and higher CRP HGNC and ferritin levels. Severe MIS HGNC-C patients had higher levels of WBC, CRP HGNC, D-dimer and ferritin. For MIS HGNC-C, younger children had lower CRP HGNC and ferritin levels than medium-aged/older children. Measurement of inflammatory markers might assist clinicians in accurate evaluation and diagnosis of MIS HGNC-C and the associated disorders.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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