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HGNC Genes

SARS-CoV-2 proteins

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SARS-CoV-2 Proteins
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    Association of inflammatory markers with the severity of COVID-19 MESHD

    Authors: Furong Zeng; Ying Guo; Mingzhu Yin; Xiang Chen; Guangtong Deng

    doi:10.1101/2020.04.14.20065680 Date: 2020-04-17 Source: medRxiv

    Background: The ongoing worldwide epidemic of Coronavirus Disease MESHD Coronavirus Disease 2019 MESHD ( COVID-19 MESHD), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has posed a huge threat to global public health. However, with regard to the effects of inflammatory markers on the severity of COVID-19 MESHD, studies have reported associations that vary in strength and direction. Aims: In the meta-analysis, we aimed to provide an overview of the association of inflammatory markers with severity of COVID-19 MESHD. Methods: The following databases were searched: PubMed, Embase, Cochrane Library, Wanfang database and CNKI (China National Knowledge Infrastructure) database until March 20, 2020. Weighted mean difference ( WMD MESHD) and 95% confidence intervals (CIs) were pooled using random or fixed-effects models. Results: A total of 16 studies were included in our analysis comprising of 3962 patients with COVID-19 MESHD. Random-effects results demonstrated that patients with COVID-19 MESHD in non-severe group had lower levels for CRP HGNC (WMD = -41.78 mg/l, 95% CI = [-52.43, -31.13], P < 0.001), PCT HGNC (WMD = -0.13 ng/ml, 95% CI = [-0.20, -0.05], P < 0.001), IL-6 HGNC (WMD = -21.32 ng/l, 95% CI = [-28.34, -14.31], P < 0.001), ESR (WMD = -8.40 mm/h, 95% CI = [-14.32, -2.48], P = 0.005), SAA (WMD = -43.35 g/ml, 95% CI = [-80.85, -5.85], P = 0.020) and serum ferritin (WMD = -398.80 mg/l, 95% CI = [-625.89, -171.71], P < 0.001), compared with those in severe group. Moreover, survivors had lower level for IL-6 HGNC than non-survivors with COVID-19 MESHD (WMD = -4.80 ng/ml, 95% CI = [-5.87, -3.73], P < 0.001). These results were consistent through sensitivity analysis and publication bias assessment. Conclusions: The meta-analysis highlights the association of inflammatory markers with the severity of COVID-19 MESHD. Measurement of inflammatory markers might help clinicians to monitor and evaluate the severity and prognosis of COVID-19 MESHD.

    Clinical characteristics of 25 death cases infected with COVID-19 MESHD pneumonia: a retrospective review of medical records in a single medical center, Wuhan, China

    Authors: Xun Li; Luwen Wang; Shaonan Yan; Fan Yang; Longkui Xiang; Jiling Zhu; Bo Shen; Zuojiong Gong

    doi:10.1101/2020.02.19.20025239 Date: 2020-02-25 Source: medRxiv

    Summary Background The pneumonia MESHD caused by the 2019 novel coronavirus (SARS-CoV-2) is a highly infectious disease MESHD, which was occurred in Wuhan, Hubei Province, China in December 2019. As of February 13, 2020, a total of 59883 cases of COVID-19 MESHD in China have been confirmed and 1368 patients have died from the disease. However, the clinical characteristics of the dyed patients were still not clearly clarified. This study aims to summarize the clinical characteristics of death cases with COVID-19 MESHD and to identify critically ill patients of COVID-19 MESHD early and reduce their mortality. Methods The clinical records, laboratory findings and radiologic assessments included chest X-ray or computed tomography were extracted from electronic medical records of 25 died patients with COVID-19 MESHD in Renmin Hospital of Wuhan University from Jan 14 to Feb 13, 2020. Two experienced clinicians reviewed and abstracted the data. Findings The mean age of the dead was 71.48 years, the average course of the disease was 10.56 days, all patients eventually died of respiratory failure MESHD. All of those who died had underlying diseases, the most common of which was hypertension MESHD (16/25, 64%), followed by diabetes MESHD (10/25, 40%), heart diseases MESHD (8/25, 32%), kidney diseases MESHD (5/25, 20%), cerebral infarction MESHD (4/25, 16%), chronic obstructive pulmonary disease MESHD ( COPD MESHD, 2/25, 8%), malignant tumors MESHD (2/25, 8%) and acute pancreatitis MESHD (1/25, 4%). The most common organ damage outside the lungs was the heart, followed by kidney and liver. In the patients' last examination before death MESHD, white blood cell and neutrophil counts were elevated in 17 patients (17/25, 68%) and 18 patients (18/25, 72%), lymphocyte counts were decreased in 22 patients (22/25, 88%). Most patients' PCT HGNC, CRP HGNC and SAA levels were elevated, the percentages were 90.5% (19/21), 85% (19/20) and 100% (21/21) respectively. The levels of the last test of neutrophils (15/16, 93.8%), PCT HGNC (11/11, 100%), CRP HGNC (11/13, 84.6%), cTnI HGNC (8/9, 88.9%), D-Dimer (11/12, 91.6%) and LDH (9/9, 100%) were increased as compared to the first test, while the levels of lymphocytes were decreased (14/16, 87.5%). Interpretation The age and underlying diseases ( hypertension MESHD, diabetes MESHD, etc.) were the most important risk factors for death of COVID-19 MESHD pneumonia MESHD. Bacterial infections may play an important role in promoting the death of patients. Malnutrition MESHD was common to severe patients. Multiple organ dysfunction can be observed, the most common organ damage was lung, followed by heart, kidney and liver. The rising of neutrophils, SAA, PCT HGNC, CRP HGNC, cTnI HGNC, D-Dimer and LDH levels can be used as indicators of disease progression, as well as the decline of lymphocytes counts.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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