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HGNC Genes

SARS-CoV-2 proteins

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    SEVERE COVID-19 MESHD IS MARKED BY DYSREGULATED SERUM LEVELS OF CARBOXYPEPTIDASE A3 HGNC AND SEROTONIN MESHD

    Authors: Rodolfo Soria-Castro; Yatsiri G. Meneses-Preza; Gloria M. Rodriguez-Lopez; Sandra Romero-Ramirez; Victor A. Sosa-Hernandez; Rodrigo Cervantes-Diaz; Alfredo Perez-Fragoso; Jose J Torres-Ruiz; Diana Gomez-Martin; Marcia Campillo-Navarro; Violeta D. Alvarez-Jimenez; Sonia M. Perez-Tapia; Alma D. Chavez-Blanco; Sergio Estrada-Parra; Jose L. Maravillas-Montero; Rommel Chacon-Salinas

    doi:10.1101/2021.02.02.21251020 Date: 2021-02-03 Source: medRxiv

    The immune response plays a critical role in the pathophysiology of SARS-CoV-2 infection MESHD ranging from protection to tissue damage. This is observed in the development of acute respiratory distress syndrome MESHD when elevated levels of inflammatory cytokines are detected. Several cells of the immune response are implied in this dysregulated immune response including innate immune cells and T and B cell lymphocytes. Mast cells are abundant resident cells of the respiratory tract, able to rapidly release different inflammatory mediators following stimulation. Recently, mast cells have been associated with tissue damage during viral infections, but little is known about their role in SARS-CoV-2 infection MESHD. In this study we examined the profile of mast cell activation markers in the serum of COVID-19 MESHD patients. We noticed that SARS-CoV-2 infected MESHD patients showed increased carboxypeptidase A3 HGNC ( CPA3 HGNC), and decreased serotonin levels in their serum. CPA3 HGNC levels correlated with C-reactive protein HGNC, the number of circulating neutrophils and quick SOFA. CPA3 HGNC in serum was a good biomarker for identifying severe COVID-19 MESHD patients, while serotonin was a good predictor of SARS-CoV-2 infection MESHD. In summary, our results show that serum CPA3 HGNC and serotonin levels are relevant biomarkers during SARS-CoV-2 infection MESHD, suggesting that mast cells are relevant players in the inflammatory response in COVID-19 MESHD, might represent targets for therapeutic intervention.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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