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MeSH Disease

COVID-19 (1)


HGNC Genes

SARS-CoV-2 proteins

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    Alimentary System is Directly Attacked by SARS-COV-2 and Further Prevents Immune Dysregulation Caused by COVID-19 MESHD

    Authors: Sai Chen; Jing Zhou; Xiaoqi Ou UG; Wei Cheng; Yun Qin; Yingqiang Guo; Yunhan Jiang

    doi:10.21203/rs.3.rs-56005/v2 Date: 2020-08-08 Source: ResearchSquare

    Background. SARS-COV-2 causes digestive system symptom, the effect of which remains equivocal.Methods. Patients with COVID-19 MESHD were classified into 4 groups according to symptom. The study traced the onset and duration of symptoms, compared laboratory examinations and conducted bioinformatic analysis. Immune indices were further analyzed.Results. By March 16, 25 patients with COVID-19 MESHD and 13 with suspect COVID-19 MESHD were admitted to West China Hospital, Sichuan University. Digestive system symptom group had the highest level of ESR (mm/h, P<0.0001), serum ferritin (ng/ml, P<0.0001), hepatic enzymes (P<0.05), and retentive lymphocyte count/percentage (P<0.05) and its subsets (P<0.05). Combined group (respiratory combined with subsequent digestive system symptom) had the highest level of IL-6 HGNC (pg/ml, P=0.0046), CRP HGNC (mg/L, P=0.0004) and moderate lymphocyte depletion. Respiratory system symptom and asymptomatic groups suffered the most from lymphocyte depletion (P<0.05). Bioinformatic analysis indicated co-expression of binding related proteins of SARS-COV-2 ( ACE2 HGNC, TMPRSS2 HGNC and Furin HGNC) in small intestine. CD147 HGNC was extensively expressed in alimentary tract. CTSL HGNC, PIKfyve, TPC2 HGNC and CTSB HGNC could be detected with ≥moderate expressions in a variety of organs including alimentary system.Conclusions. Alimentary system is directly attacked by SARS-COV-2 other than hyperinflammation and immune dysregulation. Involvement of alimentary system might further protect mild and moderate cases from lymphocyte depletion caused by COVID-19 MESHD.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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