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MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

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    Identification of immunological, inflammatory, hematological, and coagulation abnormalities associated with severity and mortality of COVID-19 MESHD: a meta-analysis of 64 observational studies

    Authors: Li He; Rundong Qin; Zhaowei Yang; Nan Jia; Ruchong Chen; Jiaxing Xie; Wanyi Fu; Hao Chen; Xinliu Lin; Renbin Huang; Tian Luo; Yukai Liu; Siyang Yao; Mei Jiang; Jing Li

    doi:10.21203/rs.3.rs-74207/v1 Date: 2020-09-08 Source: ResearchSquare

    BackgroundLaboratory abnormalities associated with disease severity and mortality in patients with coronavirus disease 2019 MESHD ( COVID-19 MESHD) have been reported in many observational studies. However, there are significant heterogeneities in patient characteristics and research methodologies in these studies.ObjectivesWe aimed to provide an updated synthesis of the association between laboratory abnormalities MESHD and COVID-19 MESHD prognosis.MethodsWe conducted an electronic search of PubMed, Scopus, Ovid, Willey, Web of Science, and the China National Knowledge Infrastructure (CNKI) for studies reporting hematological, coagulation, inflammatory, and immunological results during hospital admission of COVID-19 MESHD patients with different severities and outcomes.ResultsA total of 64 studies were included in the current meta-analysis, with 8 hematological, 3 coagulation, 5 inflammatory, and 23 immunological variables reported. Of them, white blood cell (WBC) and neutrophil counts ( Neu HGNC), D-dimer level, procalcitonin (PCT), erythrocyte sedimentation rate (ESR), C-reactive protein HGNC ( CRP HGNC), ferretin, serum amyloid A (SAA), interleukins (ILs)–2R, IL-6 HGNC, and IL-10 HGNC were significantly increased in severely ill patients and non-survivors. Meanwhile, non-severely ill patients and survivors presented significantly higher counts of eosinophils, lymphocytes, and CD4+ and CD8+ T cells. A majority of included variables presented with significant heterogeneity, some of which resulted from differing disease severities and ages of included patients.ConclusionsThe current meta-analysis provides a comprehensive and updated synthesis of the association between admission laboratory abnormalities with severity and mortality of COVID-19 MESHD. Our results highlight that increases in the levels of PCT, ESR, CRP HGNC, ferretin, SAA, IL-2R HGNC, IL-6 HGNC, and IL-10 HGNC were associated with disease deterioration, whereas elevated eosinophils, lymphocytes, and T-cell subsets might serve as indicators of favorable outcomes.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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