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HGNC Genes

SARS-CoV-2 proteins

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    Galectin-3 HGNC as a potential prognostic biomarker of severe COVID-19 MESHD in SARS-CoV-2 infected MESHD patients

    Authors: Eduardo Cervantes-Alvarez; Nathaly Limon-de la Rosa; Moises Salgado-de la Mora; Paola Valdez-Sandoval; Mildred Palacios-Jimenez; Fatima Rodriguez-Alvarez; Brenda I. Vera-Maldonado; Eduardo Aguirre-Aguilar; Juan Manuel Escobar-Valderrama; Jorge Alanis-Mendizabal; Osvely Mendez-Guerrero; Farid Tejeda-Dominguez; Jiram Torres-Ruiz; Diana Gomez-Martin; Kathryn L. Colborn; David Kershenobich; Christene A. Huang; Nalu Navarro-Alvarez

    doi:10.1101/2021.02.07.21251281 Date: 2021-02-09 Source: medRxiv

    BACKGROUNDPrognostic biomarkers are needed to identify patients at high-risk for severe COVID-19 MESHD. Galectin-3 HGNC is known to drive neutrophil infiltration and release of pro-inflammatory cytokines contributing to airway inflammation MESHD. METHODSIn this prospective cohort, we assessed galectin-3 HGNC levels in 156 hospitalized patients with confirmed COVID-19 MESHD. COVID-19 MESHD patients were diagnosed as either critical (>50% lung damage MESHD) or moderate (<50% of lung damage MESHD) based on computerized tomography. Patients who required invasive mechanical ventilation (IMV) and/or died during hospitalization were categorized as having a severe outcome, and a non-severe outcome if they were discharged and none of the former occurred. RESULTSElevated serum galectin-3 HGNC was significantly higher in critical patients compared to moderate ones (35.91 {+/-} 19.37 ng/mL vs. 25 {+/-} 14.85 ng/mL, p<0.0001). Patients who progressed to a severe outcome including IMV and/or in-hospital death, presented higher galectin-3 HGNC levels (41.17 ng/mL [IQR 29.71 - 52.25] vs. 23.76 ng/mL [IQR 15.78 - 33.97] compared to those of a non-severe outcome, p<0.0001). Galectin-3 HGNC discriminated well between those with severe and non-severe outcome, with an AUC of 0.75 (95% CI 0.67 - 0.84, p<0.0001) and was found to be an independent predictor of severe outcome regardless of the percentage of lung involvement. Additionally, the combination of galectin-3 HGNC, CRP HGNC and albumin, significantly improved its individual predicting ability with an AUC 0.84 (95% CI 0.77 - 0.91, p<0.0001). CONCLUSIONCirculating galectin-3 HGNC levels can be used to predict severe outcomes in COVID-19 MESHD patients, including the requirement of mechanical ventilation and/or death MESHD, regardless of the initial severity of the disease.

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MeSH Disease
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SARS-CoV-2 Proteins


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