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HGNC Genes

SARS-CoV-2 proteins

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    Metabolic Consequences Of Obesity On The Hypercoagulable State Of Polycystic Ovary Syndrome: A Risk For Severe SARS-Cov-2 Infection MESHD?

    Authors: Abu Saleh Md Moin; Thozhukat Sathyapalan; Ilhame Diboun; Mohamed Elrayess; Alexandra E Butler; Stephen L Atkin

    doi:10.21203/rs.3.rs-76784/v1 Date: 2020-09-12 Source: ResearchSquare

    Introduction:  Polycystic ovary syndrome MESHD ( PCOS MESHD) women have a hypercoagulable state and are also at high risk for severe COVID-19 MESHD leading to thromboembolic complications MESHD and increased mortality; however, whether this is intrinsically due to PCOS MESHD or, alternatively, a consequence of its metabolic complications is unclear.  Methods: We determined plasma coagulation pathway protein levels in PCOS MESHD (n=146) and control (n=97) women recruited to a PCOS MESHD biobank. Circulating levels of a panel of 18 clotting pathway proteins were determined by Slow Off-rate Modified Aptamer (SOMA)-scan plasma protein measurement.Results: Cohorts were age matched, though PCOS MESHD had elevated body mass index (BMI)(p<0.001), insulin HGNC (p<0.001) and C-reactive protein HGNC ( CRP HGNC)(p<0.0001). Eight pro-coagulation proteins were elevated in PCOS MESHD: plasminogen activator inhibitor-1 HGNC ( PAI-1 HGNC)(p<0.0001), fibrinogen HGNC (p<0.01), fibrinogen gamma chain HGNC (p<0.0001), fibronectin HGNC (p<0.01), von Willebrand MESHD factor (p<0.05), D-dimer (p<0.0001), P-selectin HGNC (p<0.05), and plasma kallikrein (p<0.001). However, two anticoagulant proteins, vitamin K-dependent protein-S HGNC protein-S PROTEIN (p<0.0001) and heparin cofactor-II (p<0.001) were elevated and prothrombin was decreased (p<0.05). CRP HGNC, as a marker of inflammation MESHD, and insulin HGNC resistance (HOMA-IR) correlated with 11 and 6 of the clotting proteins, respectively (p<0.05). When matched for BMI<25 (16 PCOS MESHD, 53 controls) HOMA-IR remained elevated (p<0.05) and heparin cofactor-II was increased (p<0.05). In a multivariate analysis accounting for inflammation MESHD, insulin HGNC resistance and BMI, there was no correlation of PCOS MESHD with any of the coagulation proteins.Conclusion: The hypercoagulable State in PCOS MESHD can be fully accounted for by BMI, inflammation MESHD and insulin HGNC resistance suggesting that only obese PCOS MESHD women would be predisposed to an enhanced risk for severe COVID-19 MESHD-related disease.

    Hyperpyrexia leading to death in a patient with severe COVID-19 MESHD disease

    Authors: Tanu Singhal; Sourabh Phadtare; Sunil Pai; Amit Raodeo

    doi:10.1101/2020.05.18.20097220 Date: 2020-05-20 Source: medRxiv

    We describe here clinical course of a 42 year old male with severe COVID-19 MESHD disease treated at a private hospital in Mumbai India. This patient with very high inflammatory markers at admission was treated with supportive care, mechanical ventilation, anticoagulation, hydroxychloroquine, corticosteroids, tocilizumab, intravenous insulin HGNC, antibiotics, sedation and paralysis MESHD. There was sustained improvement in his respiratory status and decline in ventilator settings with decline and normalization of CRP HGNC, D dimer and PCT. However high fever persisted that did not respond to paracetamol and NSAIDS. On day 8 of admission his axillary temperature touched 107F followed by rapid clinical deterioration and death within the next 12 hours, Blood cultures were consistently sterile.

    Higher Body Mass Index is an Important Risk factor in COVID-19 MESHD patients: A Systematic Review

    Authors: Vivek Singh Malik; Ravindra Khaiwal; Savita Verma Attri; Sanjay Kumar Bhadada; Meenu Singh

    doi:10.1101/2020.05.11.20098806 Date: 2020-05-18 Source: medRxiv

    Background: Globally, both obesity MESHD and underweight are severe health risks for various diseases. The current study systematically examines the emerging evidence to identify an association between Body Mass Index (BMI) and COVID-19 MESHD disease outcome. Methods: Online literature databases (e.g., Google Scholar, PubMed, MEDLINE, EMBASE, Scopus, Medrixv and BioRixv) were screened following standard search strategy having the appropriate keyword such as Obesity, Underweight, BMI, Body Mass Index, 2019-nCov, COVID-19 MESHD, novel coronavirus, coronavirus disease MESHD. Studies published till 20th April 2020 were included without language restriction. These studies include case reports, case series, cohort, and any other which reported BMI, overweight/ obesity MESHD or underweight, and its complication with COVID-19 MESHD disease. Findings: Obesity plays a significant part in the pathogenesis of COVID-19 MESHD patients, though the role of BMI in the COVID-19 pandemic MESHD must not be ignored. Interpretation: Consequences of inflammation of adipose MESHD tissue has been reported as a leading cause of insulin HGNC resistance and hypertension MESHD due to metabolic dysfunction MESHD. The results of the current study show that BMI plays a significant role in COVID-19 MESHD severity in all ages, especially the elderly population. A panel should review COVID-19 MESHD patients with higher BMI and other co-morbidities, and they should be given increased vigilance, testing priority, and therapy. Further, the COVID-19 MESHD patients whose illness entered 7-10 days, age >50 yrs, and elevated CRP HGNC levels should have additional medical considerations. Recommendation: Population and patients with high BMI have moderate to high risk of medical complications with COVID-19 MESHD, and hence their health status should be monitored more frequently. Keywords: Age, BMI, COVID-19 MESHD, Obesity.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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