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MeSH Disease

COVID-19 (1)


HGNC Genes

SARS-CoV-2 proteins

There are no SARS-CoV-2 protein terms in the subcorpus


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    Plasma Levels of Phospholipids in Patients With COVID-19 MESHD; A Promising Simple Biochemical Parameter to Evaluate the Disease Severity

    Authors: Mohammed Abdalla; Noor Eldin Mohamed Ismail; ahmed h mohamed; Rita M Borik; Ali a ali; Yasser O Mosaad

    doi:10.21203/rs.3.rs-57302/v1 Date: 2020-08-11 Source: ResearchSquare

    Background Cronavirus-19 ( COVID-19 MESHD) pandemic is a worldwide public health problem knowing in China recently from December 25, 2019. Phospholipids are structural components of mammalian cytoskeleton and cell membranes. Phospholipids is an anionic lipid found in mammalian membranes in low amounts (1–2%) of the total phospholipids. Also, it suppressed viral attachment to the plasma membrane and subsequent replication in lung cells.  Aim: The present study was carried out to explain the correlation between the plasma phospholipids as well as secretory phospholipase-A2α2 (sPLA2α2) and cytokine storm; tumor necrosis factor ( TNF)-α HGNC, interleukin--1β HGNC ( IL-1β HGNC), interleukin-6 (IL)-6 HGNC and interleukin-13 HGNC ( IL-13_ HGNC levels of patients with COVID-19 MESHD to assess the infection severity. Methods: Serum samples from enrolled 34 patients with mild, moderate, and acute COVID-19 MESHD infection. Complete blood picture (CBC), plasma d-dimer, ferritin, C-reactive protein HGNC ( CRP HGNC), lipid profile, phospholipids, sPLA2α2 and TNF-α HGNC, IL-1β HGNC, IL-6 HGNC and IL-13 HGNC as well as lung computed tomography (CT) imaging.Results: CBC showed that the presence of leukopenia, lymphopenia, eosinopenia in patient with mild, moderate, and acute COVID-19 MESHD infection. Also, significant increase in plasma d-dimer, CRP HGNC, ferritin, triacyclglycerols, TNF-α HGNC, IL-1β HGNC, IL-6 HGNC and IL-13 HGNC levels as well as sPLA2α2 activity when compared to normal persons. However, plasma levels of phospholipids, cholesterol, HDL-C and LDL-C were decreased significantly in patient with acute COVID-19 MESHD infection only, when compared to normal persons. In addition, lung computed tomography (CT) scan showed that the presence of ground glass opacity (GGO), bronchial wall thickening, crazy paving sign as well as right, left, upper and lower lung predominant in patient with mild, moderate and acute COVID-19 MESHD infection. The levels of blood leukopenia, lymphopenia and eosinopenia as well as plasma phospholipids d-dimer, CRP HGNC, ferritin, cytokine storm and sPLA2α2 were pronounced in group of patients with acute COVID-19 MESHD infection more the mild and moderate one.Conclusion: The present study was showed that there is a correlation between plasma phospholipids depletion as well as elevation sPLA2α2 and cytokines storm with the severity of COVID-19 MESHD infection. Also, the plasma phospholipids levels can used to estimate COVID-19 MESHD infection severity and help to identify patients into three classes: mild, moderate and severe one.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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