Corpus overview


MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

There are no SARS-CoV-2 protein terms in the subcorpus


SARS-CoV-2 Proteins
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    Acute kidney injury in patients hospitalized with COVID-19 MESHD in Wuhan, China: A single-center retrospective observational study

    Authors: Guanhua Xiao; Hongbin Hu; Feng Wu; Tong Sha; Qiaobing Huang; Haijun Li; Jiafa Han; Wenhong Song; Zhongqing Chen; Zhenhua Zeng

    doi:10.1101/2020.04.06.20055194 Date: 2020-04-08 Source: medRxiv

    Background: The kidney may be affected in coronavirus-2019 disease ( COVID-19 MESHD). This study assessed the predictors and outcomes of acute kidney injury MESHD ( AKI MESHD) among individuals with COVID-19 MESHD. Methods: This observational study, included data on all patients with clinically confirmed COVID-19 MESHD admitted to Hankou Hospital, Wuhan, China from January 5 to March 8 HGNC, 2020. Data were extracted from clinical and laboratory records. Follow-up was censored on March 8 HGNC, 2020. This is a single-center, retrospective, observational study. Patients clinically confirmed COVID-19 MESHD and admitted to Hankou Hospital, Wuhan, China from January 5 to March 8 HGNC, 2020 were enrolled. We evaluated the association between changes in the incidence of AKI MESHD and COVID-19 MESHD disease and clinical outcomes by using logistic regression models. Results: A total of 287 patients, 55 with AKI MESHD and 232 without AKI MESHD, were included in the analysis. Compared to patients without AKI MESHD, AKI MESHD patients were older, predominantly male, and were more likely to present with hypoxia MESHD and have pre-existing hypertension MESHD and cerebrovascular disease MESHD. Moreover, AKI MESHD patients had higher levels of white blood cells, D-dimer, aspartate aminotransferase, total bilirubin, creatine kinase, lactate dehydrogenase, procalcitonin, C-reactive protein HGNC, a higher prevalence of hyperkalemia MESHD, lower lymphocyte counts, and higher chest computed tomographic scores. The incidence of stage 1 AKI MESHD was 14.3%, and the incidence of stage 2 or 3 AKI MESHD was 4.9%. Patients with AKI MESHD had substantially higher mortality. Conclusions: AKI MESHD is an important complication of COVID-19 MESHD. Older age, male, multiple pre-existing comorbidities, lymphopenia MESHD, increased infection indicators, elevated D-dimer, and impaired heart and liver functions MESHD were the risk factors of AKI MESHD. AKI MESHD patients who progressed to stages 2 or 3 AKI MESHD had a higher mortality rate. Prevention of AKI MESHD and monitoring of kidney function is very important for COVID 19 patients.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins

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