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HGNC Genes

SARS-CoV-2 proteins

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    Detection of serum KL-6 HGNC and SARS-CoV-2 antibody in patients with coronavirus disease 2019 MESHD and the diagnostic value in severe disease

    Authors: Huiyan Wang; Lichang Chen; Yang Zhang; Long Liu; Meimei Xu; Yong Gao; Ming Li

    doi:10.21203/rs.3.rs-125188/v2 Date: 2020-12-09 Source: ResearchSquare

    Background Coronavirus disease 2019 MESHD ( COVID-19 MESHD) caused by severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) is a significant threat to human health, but its clinical manifestations vary greatly among individuals. Early detection and treatment are important for severely ill patients to improve their prognosis and reduce the risk of death MESHD.Methods In the present study, serum markers were detected and analyzed in moderately ill and severely ill patients.Results The results found that there were statistically significant differences in age, serum Krebs von MESHD den Lungen-6 ( KL-6 HGNC) and Immunoglobulin A (IgA) HGNC levels between severely ill patients and moderately ill patients (Pā€‰<ā€‰0.05). The cut-off of using KL-6 HGNC alone for the diagnosis of severely ill patients was 298.91 U/mL, with an AUC of 0.737, a sensitivity of 100%, and a specificity of 43%. When the diagnosis was performed using KL-6 HGNC in combination with Interleukin-6 HGNC ( IL-6 HGNC), an indicator of infection, the AUC was 0.776, with a sensitivity and specificity of 82% and 69%, respectively. When the three above were used in combination for diagnosis, the AUC was 0.785, and the sensitivity and specificity were 100% and 59%, respectively. After rehabilitation, the serum levels of KL-6 HGNC, C-reactive protein HGNC ( CRP HGNC), as well as antibodies, IgA, IgM and IgG, were significantly lower than those in the early stage of hospitalization.Conclusion In the present study, KL-6 HGNC and IgA were found to have some diagnostic efficacy for severely ill patients with COVID-19 MESHD, but larger cohort studies are still needed for further confirmation, which in turn improves the diagnostic and therapeutic efficiency of severely ill patients.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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