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MeSH Disease

Obesity (1)

COVID-19 (1)


HGNC Genes

SARS-CoV-2 proteins

There are no SARS-CoV-2 protein terms in the subcorpus


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    Obesity as a risk factor for unfavourable outcomes in critically ill patients affected by Covid-19 MESHD related respiratory failure: clinical relevance and potential pathophysiological mechanism.

    Authors: Andrea P Rossi; Leonardo Gottin; Katia Donadello; Vittorio Schweiger; Riccardo Nocini; Matteo Taiana; Mauro Zamboni; Enrico Polati

    doi:10.21203/rs.3.rs-40844/v1 Date: 2020-07-09 Source: ResearchSquare

    Background/Objectives: Recent studies show that obesity MESHD is a risk factor for hospital admission and for critical care need in patients with coronavirus disease 2019 MESHD ( COVID-19 MESHD).The aim was to determine whether obesity MESHD is a risk factor for unfavourable health outcomes in patients affected by COVID-19 MESHD admitted to ICU and to compare the observed trend of C-Reactive Protein (CRP) and Creatine Phosphokinase ( CPK HGNC), as potential pathophysiological mechanisms linking disease severity with Body Mass Index (BMI).Subjects/Methods: 95 consecutive patients with COVID-19 MESHD (78 males and 18 females) were admitted to ICU and included in the study. Height, weight, BMI, Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation II (APACHE II) scores, CRP HGNC, CPK HGNC, as well as ICU and hospital length of stay and comorbidities were evaluated. Results: Participants with obesity MESHD had a lower 28 day survival rate from ICU admission than normal weight subjects. Cox proportional hazard model-derived estimates, adjusted for age, gender and comorbidity, confirmed the results of the survival analysis (HR:5.30,95%C.I.1.26-22.34). In the full adjusted model, age was independently associated with mortality (HR:1.13,95%C.I:1.05-1.21). Obese MESHD subjects showed longer hospital and ICU stay as compared with normal weight counterpart.Subjects with obesity MESHD showed significantly higher CRP HGNC and CPK HGNC levels than normal weight subjects.Conclusions: Our study shows that in COVID-19 MESHD subjects admitted to ICU obesity MESHD is a risk factor for unfavourable health outcomes with higher mortality and longer hospital stay. The increase in CRP HGNC and CPK HGNC levels observed in this population could at least in part explain the unfavourable outcomes observed in individuals with obesity MESHD. In those subjects, careful management of any medical signs or symptoms and prompt intervention in case of suspected SARS-CoV-2 infection MESHD is necessary to prevent the progression of the disease towards severe outcomes and the increase of hospital treatment costs.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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