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HGNC Genes

SARS-CoV-2 proteins

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    Metabolic Consequences Of Obesity On The Hypercoagulable State Of Polycystic Ovary Syndrome: A Risk For Severe SARS-Cov-2 Infection MESHD?

    Authors: Abu Saleh Md Moin; Thozhukat Sathyapalan; Ilhame Diboun; Mohamed Elrayess; Alexandra E Butler; Stephen L Atkin

    doi:10.21203/rs.3.rs-76784/v1 Date: 2020-09-12 Source: ResearchSquare

    Introduction:  Polycystic ovary syndrome MESHD ( PCOS MESHD) women have a hypercoagulable state and are also at high risk for severe COVID-19 MESHD leading to thromboembolic complications MESHD and increased mortality; however, whether this is intrinsically due to PCOS MESHD or, alternatively, a consequence of its metabolic complications is unclear.  Methods: We determined plasma coagulation pathway protein levels in PCOS MESHD (n=146) and control (n=97) women recruited to a PCOS MESHD biobank. Circulating levels of a panel of 18 clotting pathway proteins were determined by Slow Off-rate Modified Aptamer (SOMA)-scan plasma protein measurement.Results: Cohorts were age matched, though PCOS MESHD had elevated body mass index (BMI)(p<0.001), insulin HGNC (p<0.001) and C-reactive protein HGNC ( CRP HGNC)(p<0.0001). Eight pro-coagulation proteins were elevated in PCOS MESHD: plasminogen activator inhibitor-1 HGNC ( PAI-1 HGNC)(p<0.0001), fibrinogen HGNC (p<0.01), fibrinogen gamma chain HGNC (p<0.0001), fibronectin HGNC (p<0.01), von Willebrand MESHD factor (p<0.05), D-dimer (p<0.0001), P-selectin HGNC (p<0.05), and plasma kallikrein (p<0.001). However, two anticoagulant proteins, vitamin K-dependent protein-S HGNC protein-S PROTEIN (p<0.0001) and heparin cofactor-II (p<0.001) were elevated and prothrombin was decreased (p<0.05). CRP HGNC, as a marker of inflammation MESHD, and insulin HGNC resistance (HOMA-IR) correlated with 11 and 6 of the clotting proteins, respectively (p<0.05). When matched for BMI<25 (16 PCOS MESHD, 53 controls) HOMA-IR remained elevated (p<0.05) and heparin cofactor-II was increased (p<0.05). In a multivariate analysis accounting for inflammation MESHD, insulin HGNC resistance and BMI, there was no correlation of PCOS MESHD with any of the coagulation proteins.Conclusion: The hypercoagulable State in PCOS MESHD can be fully accounted for by BMI, inflammation MESHD and insulin HGNC resistance suggesting that only obese PCOS MESHD women would be predisposed to an enhanced risk for severe COVID-19 MESHD-related disease.

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MeSH Disease
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