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HGNC Genes

SARS-CoV-2 proteins

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    Effects of obesity on serum levels of SARS-CoV-2-specific antibodies in COVID-19 MESHD patients

    Authors: Daniela Frasca; Lisa Reidy; Carolyn Cray; Alain Diaz; Maria Romero; Kristin Kahl; Bonnie B Blomberg

    doi:10.1101/2020.12.18.20248483 Date: 2020-12-20 Source: medRxiv

    SARS-CoV-2 (Severe Acute Respiratory Syndrome Corona Virus-2 MESHD), cause of COVID-19 MESHD (Coronavirus Disease of 2019), represents a significant risk to people living with pre-existing conditions associated with exacerbated inflammatory responses and consequent dysfunctional immunity. In this paper, we have evaluated the effects of obesity MESHD, a condition associated with chronic systemic inflammation MESHD, on the secretion of SARS-CoV-2-specific IgG antibodies in the blood of COVID-19 MESHD patients. Results have shown that SARS-CoV-2 IgG antibodies are negatively associated with Body Mass Index (BMI) in COVID-19 MESHD obese MESHD patients, as expected based on the known effects of obesity MESHD on humoral immunity. Antibodies in COVID-19 MESHD obese MESHD patients are also negatively associated with serum levels of pro-inflammatory and metabolic markers of inflammaging and pulmonary inflammation MESHD, such as SAA ( serum amyloid A protein HGNC), CRP HGNC ( C-reactive protein HGNC) and ferritin, but positively associated with NEFA (nonesterified fatty acids). These results altogether could help to identify an inflammatory signature with strong predictive value for immune dysfunction MESHD that could be targeted to improve humoral immunity in individuals with obesity MESHD as well as with other chronic inflammatory conditions.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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