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MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

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    Potential of natural astaxanthin in alleviating the risk of cytokine storm and improve health in COVID-19 MESHD: A scoping review

    Authors: Jayanta Talukdar; Bhaskar Bhadra; Santanu Dasgupta; Vinod Nagle

    doi:10.21203/rs.3.rs-26458/v1 Date: 2020-05-02 Source: ResearchSquare

    Background: Natural astaxanthin as a potent anti-oxidant and broad-spectrum anti-inflammatory bioactive molecule plays important role in modulating the immune response, speculated to be a potential supplement to alleviate cytokine release storm in COVID-19 MESHD. Objective: Review of published literature to summarize the rationale for possible benefits of natural astaxanthin to support COVID-19 MESHD patients. Methods: Retrieved relevant literature from electronic databases including Google scholar, PubMed, Scopus, etc. and reviewed following Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) Statement. We adapted the article as scoping review. Results: Cytokine release syndrome (CRS) is reported as a common feature in COVID-19 MESHD, which can lead to potentially fatal, hyper-inflammatory acute respiratory distress condition MESHD, diagnosed with elevated serum level of pro-inflammatory cytokines like IL-6 HGNC, CRP HGNC, etc. that positively correlated with disease severity. Anti-inflammatory drug, like tocilizumab, etc. are under clinical trials as anti-CRS therapy. Astaxanthin can potentially alleviate CRS by regulating inflammatory cytokines by inhibiting the activities of NF-kB, TNF-α HGNC, JAK/ STAT-3 HGNC, etc. Available pre-clinical and clinical trials data support its excellent safety, and potential therapeutic and health benefits. Conclusions: Natural astaxanthin has tremendous potential as co-adjunctive supplement, desiring necessary clinical supports on its efficacy and beneficial against COVID-19 MESHD.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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