Corpus overview


MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

There are no SARS-CoV-2 protein terms in the subcorpus


SARS-CoV-2 Proteins
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    Dutasteride Reduces Viral Shedding, Inflammatory Responses and Time-to-Remission in COVID-19 MESHD: Biochemical Findings of a Randomized Double-Blind Placebo Controlled Interventional Trial (DUTA AndroCoV-Trial - Biochemical). 

    Authors: Flávio Adsuara Cadegiani; John McCoy; Carlos Gustavo Wambier; Andy Goren

    doi:10.21203/ Date: 2020-12-24 Source: ResearchSquare

    Importance: SARS-CoV-2 cell entry and infectivity is indirectly dependent on androgenic status and phenotype through the regulation of t ransmembrane protease serine 2 HGNC(T MPRSS2) HGNC, an androgen-mediated proteolytic enzyme that facilitates SARS-CoV-2 entry.  Males, particularly those affected by androgenetic alopecia (AGA) are overrepresented in severe COVID-19 MESHD, while the use of 5-alpha-reductase inhibitors (5ARis), an antiandrogenic drug class, may reduce COVID-19 MESHD severity. Objective: Our objective was to determine if dutasteride, a wide and potent 5ARi, would bring biochemical and virological benefits in early COVID-19 MESHD.Design, Setting, and Participants: A double-blinded, randomized, prospective, investigational study of dutasteride for the treatment of COVID-19 MESHD, as add-on therapy to the local standard of care, for mild or moderate, non-hospitalized subjects confirmed for S ARS-CoV-2 MESHD(The Duta AndroCoV Trial).Interventions:  Dutasteride 0.5mg/day or placebo for 30 days or until full COVID-19 MESHD remission. Nitazoxanide was given 500mg twice a day for six days and azithromycin was given 500mg/day for five days for all subjects.Main Outcome(s) and Measure(s): Remission times for fatigue, ageusia, anosmia, and overall disease, oxygen saturation (%), real-time polymerase chain reaction (rtPCR-SARS-CoV-2), ultrasensitive C -reactive protein HGNC(usCRP), D-dimer, lactate, dehydrogenase lactate (DHL), erythrocyte sedimentation rate (ESR), ultrasensitive troponin and ferritin.Results:  Compared to placebo group (n=44) with similar baseline characteristics, dutasteride (n=43) presented reduced fatigue, anosmia and overall disease duration (46.6%, 49.6% and 43.2% lower duration, respectively; p<.0001 for all), and in Day 7 presented higher rates of virologic cure (64.3% versus 11.8% cure; p=.0094), , increased recovery rate (84.7% versus 57.5%; p=.03), higher mean [SD] oxygen saturation (97.0% [1.4%] versus 95.7% [2.0%]; p=.02), lower median [IQR] usCRP (0.34mg/L [0.23mg/L -0.66mg/L] versus 1.47mg/L [0.70mg/L-3.37mg/L]; p<.0001),  lower median [IQR] lactate (2.01mmol/L [1.12mmol/L-2.43mmol/L] versus 2.66mmol/L [2.05mmol/L-3.55mmol/L]; p=.0049), lower median [IQR] ESR (5.0mm/1h [3.0mm/1h-11.0mm/1h] versus 14.0mm/1h [7.25mm/1h-18.5mm/1h]; p=.0007), lower median [IQR] LDH (165U/L [144U/L -198U/L] versus 210U/L [179U/L-249U/L]; p=.0013 and lower median [IQR] troponin levels (0.005ng/mL [0.003ng/mL-0.009ng/mL] versus 0.007ng/mL [0.006ng/mL-0.010ng/mL]; p=.048).Conclusions and Relevance: These findings suggest that dutasteride reduces clinical and virologic disease duration and inflammatory markers in males with mild-to-moderate, early-stage COVID-19 MESHD, and should be considered as a therapeutic option in the current context of the COVID-19 pandemic MESHD.Trial Registration: NCT04446429

    Multimodal Single-Cell Omics Analysis of COVID-19 MESHD Sex Differences in Human Immune Systems

    Authors: Yuan Hou; Yadi Zhou; Michaela Gack; Justin Lathia; Asha Kallianpur; Reena Mehra; Timothy Chan; Jae U. Jung; Lara Jehi; Charis Eng; Feixiong Cheng; Emily R Ko; Ephraim L Tsalik; gregory sempowski; Thomas N Denny; Thomas W Burke; Micah T McClain; Christopher W. Woods; Xiling Shen; Daniel R Saban; Brea Tinsley; Alan Trudeau; Jitendra Singh; Lindsey Whitmore; Helen Zheng; Matthew Benedek; Jenna Currier; Mark Dresel; Ashish Duvvuru; Britney Dyszel; Emily Fingar; Elizabeth M. Hennen; Michael Kirsch; Ali A. Khan; Charlotte Labrie-Cleary; Stephanie Laporte; Evan Lenkeit; Kailey Martin; Marilyn Orellana; Melanie Ortiz-Alvarez de la Campa; Isaac Paredes; Baleigh Wheeler; Allison Rupert; Andrew Sam; Katherine See; Santiago Soto Zapata; Paul A. Craig; Bonnie L. Hall; Jennifer Jiang; Julia R. Koeppe; Stephen A. Mills; Michael J. Pikaart; Rebecca Roberts; Yana Bromberg; J. Steen Hoyer; Siobain Duffy; Jay Tischfield; Francesc X. Ruiz; Eddy Arnold; Jean Baum; Jesse Sandberg; Grace Brannigan; Sagar D. Khare; Stephen K. Burley

    doi:10.1101/2020.12.01.407007 Date: 2020-12-01 Source: bioRxiv

    Sex differences in the risk of SARS-CoV-2 infection MESHD have been controversial and the underlying mechanisms of COVID-19 MESHD sexual dimorphism remain understudied. Here we inspected sex differences in SARS-CoV-2 positivity, hospitalization, admission to the intensive care unit (ICU), sera immune profiling, and two single-cell RNA-sequencing (snRNA-seq) profiles from nasal tissues and peripheral blood mononuclear cells (PBMCs) of COVID-19 MESHD patients with varying degrees of disease severity. Our propensity score-matching observations revealed that male individuals have a 29% increased likelihood of SARS-CoV-2 positivity, with a hazard ration (HR) 1.32 (95% confidence interval [CI] 1.18-1.48) for hospitalization and HR 1.51 (95% CI 1.24-1.84) for admission to ICU. Sera from male patients at hospital admission had decreased lymphocyte count and elevated inflammatory markers ( C-reactive protein HGNC, procalcitonin, and neutrophils). We found that SARS-CoV-2 entry factors, including ACE2 HGNC, TMPRSS2 HGNC, FURIN HGNC and NRP1 HGNC, have elevated expression in nasal squamous MESHD cells from males with moderate and severe COVID-19 MESHD. Cell-cell network proximity analysis suggests possible epithelium-immune cell interactions and immune vulnerability underlying a higher mortality in males with COVID-19 MESHD. Monocyte-elevated expression of Toll like receptor 7 HGNC ( TLR7 HGNC) and Bruton tyrosine kinase ( BTK HGNC) is associated with severe outcomes in males with COVID-19 MESHD. These findings provide basis for understanding immune responses underlying sex differences, and designing sex-specific targeted treatments and patient care for COVID-19 MESHD.

    Alimentary System is Directly Attacked by SARS-COV-2 and Further Prevents Immune Dysregulation Caused by COVID-19 MESHD

    Authors: Sai Chen; Jing Zhou; Xiaoqi Ou UG; Wei Cheng; Yun Qin; Yingqiang Guo; Yunhan Jiang

    doi:10.21203/ Date: 2020-08-08 Source: ResearchSquare

    Background. SARS-COV-2 causes digestive system symptom, the effect of which remains equivocal.Methods. Patients with COVID-19 MESHD were classified into 4 groups according to symptom. The study traced the onset and duration of symptoms, compared laboratory examinations and conducted bioinformatic analysis. Immune indices were further analyzed.Results. By March 16, 25 patients with COVID-19 MESHD and 13 with suspect COVID-19 MESHD were admitted to West China Hospital, Sichuan University. Digestive system symptom group had the highest level of ESR (mm/h, P<0.0001), serum ferritin (ng/ml, P<0.0001), hepatic enzymes (P<0.05), and retentive lymphocyte count/percentage (P<0.05) and its subsets (P<0.05). Combined group (respiratory combined with subsequent digestive system symptom) had the highest level of IL-6 HGNC (pg/ml, P=0.0046), CRP HGNC (mg/L, P=0.0004) and moderate lymphocyte depletion. Respiratory system symptom and asymptomatic groups suffered the most from lymphocyte depletion (P<0.05). Bioinformatic analysis indicated co-expression of binding related proteins of SARS-COV-2 ( ACE2 HGNC, TMPRSS2 HGNC and Furin HGNC) in small intestine. CD147 HGNC was extensively expressed in alimentary tract. CTSL HGNC, PIKfyve, TPC2 HGNC and CTSB HGNC could be detected with ≥moderate expressions in a variety of organs including alimentary system.Conclusions. Alimentary system is directly attacked by SARS-COV-2 other than hyperinflammation and immune dysregulation. Involvement of alimentary system might further protect mild and moderate cases from lymphocyte depletion caused by COVID-19 MESHD.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins

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