Corpus overview


MeSH Disease

COVID-19 (1)

HGNC Genes

SARS-CoV-2 proteins

There are no SARS-CoV-2 protein terms in the subcorpus


SARS-CoV-2 Proteins
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    The Application of Lactate Dehydrogenase in Coronavirus Disease 2019 MESHD as the Best Indicator for the Progression and Clinical Status: A Case-Control Study

    Authors: Yang Li; Xian Zhou; Jing-wen Ai; Hongyu Wang; Taoping Weng; Haocheng Zhang; Yuxian Huang; Wenhong Zhang

    doi:10.21203/ Date: 2020-08-07 Source: ResearchSquare

    Introduction Coronavirus disease 2019 MESHD ( COVID-19 MESHD) is now officially a pandemic. Current studies observed extensive abnormal indexes in COVID-19 MESHD patients and significant differences between mild and severe patients. However, which index would perform better as the indicator of disease progression merits further investigation.Methods We enrolled COVID-19 MESHD patients who were admitted to Shanghai Public Health Clinical center. We closely monitored the following candidate indictors: white blood cell, lymphocyte, platelet, CD4 T cell, CD8 T cell, alanine aminotransferase HGNC, estimated glomerular filtration rate ( eGFR HGNC), fibrin degradation products (FDP), D-dimer, creatine kinase, myoglobin HGNC, troponin T ( TnT HGNC), N-terminal pro-B-type natriuretic peptide (NT-proBNP), lactase dehydrogenase (LDH), C-reactive protein HGNC ( CRP HGNC), and procalcitonin. The correlation with illness severity were assessed by Spearman analysis and the ability of differentiating the clinical statuses was quantified as the AUC value of the ROC curve. Results A total of 326 patients were enrolled, including 299 mild-ordinary and 27 severe-critical patients. At admission, D-dimer and CRP HGNC were elevated above normal range both in mild-ordinary and severe-critical patients. LDH, NT-proBNP, myoglobin HGNC, CD4 T cell, eGFR HGNC, FDP and PCT were beyond normal range in the mild-ordinary stages of severe-critical patients, but remained normal in the persistently mild-ordinary patients. Top 5 parameters with highest spearmen coefficient were LDH, procalcitonin, NT-proBNP, myoglobin HGNC and D-dimer (Spearman coefficient: 0.488, 0.453, 0.414, 0.412, 0.407). Comparing between mild-ordinary stage and severe/critical stage, LDH showed the highest receiver operating characteristics (ROC) area under the curve (AUC) of 0.951. PCT ranked second, with the ROC AUC of 0.905. Comparing between mild-ordinary and severe stages, only LDH had the ROC AUC of over 0.90 (0.927). Conclusions This study found LDH to be a superior indicator for COVID-19 MESHD status and had the potential to optimize the clinical management strategy.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins

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