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HGNC Genes

SARS-CoV-2 proteins

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    Accuracy of routine biomarkers and blood leucocytes count to assist diagnosis of COVID-19 MESHD-associated pneumonia in adult patients visiting the emergency department

    Authors: Cécile Maincent; Frédéric Berthier; Ryan Lukas Farhad; Cristel Fissore-Magdelein; Claire Claire Dittlot; Nathalie Beau; Jérémy Lépine; Marjorie Lorillou; Matthieu Dietz; Mathieu Liberatore; Atul Pathak; Marc Marc Faraggi; Sylvie Chaillou-Orpitz; Olivia Keita-Perse; Gilles Chironi; Christophe Perrin; Yann-Erick Claessens

    doi:10.21203/rs.3.rs-34817/v1 Date: 2020-06-12 Source: ResearchSquare

    Background To investigate whether routine biomarkers and blood leucocytes count could assist diagnosis of COVID-19 MESHD-associated pneumonia MESHD in adult patients visiting the emergency department (ED). Methods This monocentre retrospective study enrolled 254 patients with nasopharyngeal RT-PCR for SARS-COV-2, routine biomarkers (D-dimers, fibrinogen HGNC, C-reactive protein HGNC, procalcitonin, NTpro-BNP, cTnT HGNC-hs) and blood cell counts. Sensitivity and specificity were evaluated. An adjudication committee classified diagnostic probability as certain, probable, unlikely, and excluded, based on all available data, then distributed in 2 categories: high (certain and probable) and low probability (unlikely and excluded). Results Between 25 th of February and 15 th of April, 2020, 254 of 388 patients could be analyzed. The adjudication committee classified 46 patients as definite, 18 as probable, 64 as unlikely, and 126 as excluded, corresponding to 64 high and 190 low probability. High and low probability patients differed for fibrinogen HGNC (P<0.0005) and white blood cell counts, notably leucocytes (P=0.0015), neutrophilic (P=0.0036), lymphocytes (P=0.0057), eosinophilic (P=0.027), and basophilic (P<0.001) counts. In a multivariate analysis, basophilic count < 25/µL (OR 3.048 [95%CI; 1.34-6.919]), neutrophilic count < 4000 /µL (OR 5.525 [95%CI; 2.20-13.855], and fibrinogen HGNC > 3g/L (OR 6355 [95%CI; 2.01-20.079] were independently associated with the diagnosis. Negative predictive values were 0.98 and 0.93 combining fibrinogen HGNC ( < 3g/L) and eosinophilic count ( < 80/µL), and fibrinogen HGNC and basophilic count ( < 25/µL), respectively. Conclusion Changes in fibrinogen HGNC and white blood cells, notably basophilic count, showed interesting performance for the diagnosis COVID-19 MESHD associated pneumonia. Combining fibrinogen HGNC with either eosinophilic or basophilic count was helpful to exclude the diagnosis.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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