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MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

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    The Role of Vitamin D in Suppressing Cytokine Storm in COVID-19 MESHD Patients and Associated Mortality

    Authors: Ali Daneshkhah; Vasundhara Agrawal; Adam Eshein; Hariharan Subramanian; Hemant Kumar Roy; Vadim Backman

    doi:10.1101/2020.04.08.20058578 Date: 2020-04-10 Source: medRxiv

    Abstract Objectives To investigate the possible role of Vitamin D (Vit D) deficiency via unregulated inflammation MESHD in COVID-19 MESHD complications and associated mortality. Design The time-adjusted case mortality ratio (T-CMR) was estimated as the number of deceased patients on day N divided by the number of confirmed cases on day N-8. The adaptive average of T-CMR (A-CMR) was further calculated as a metric of COVID-19 MESHD associated mortality in different countries. A model based on positivity change (PC) and an estimated prevalence of COVID-19 MESHD was developed to determine countries with similar screening strategies. Mean concentration of 25-hydroxyvitamin D (25(OH)D) in elderly individuals in countries with similar screening strategies were compared to investigate the potential impact of Vit HGNC D on A-CMR. We analyzed data showing a possible association between high C-Reactive Protein HGNC ( CRP HGNC) concentration ( CRP HGNC greater than or equal to 1 mg/dL) and severe COVID-19 MESHD. We estimated a link between Vit HGNC D status and high CRP HGNC in healthy subjects ( CRP HGNC greater than or equal to 0.2 mg/dL) with an adjustment for age and income to explore the possible role of Vit HGNC D in reducing complications attributed to unregulated inflammation MESHD and cytokine production. Data Sources Daily admission, recovery, and deceased rate data for patients with COVID-19 MESHD were collected from Kaggle as of April 20, 2020. Screening data were collected from Our World in Data and official statements from public authorities. The mean concentration of 25(OH)D among the elderly for comparison with A-CMR was collected from previously published studies from different countries. Chronic factor data used in regression analysis was obtained from published articles. The correlation between Vit HGNC D and CRP HGNC was calculated based on 9,212 subject-level data from NHANES, 2009-2010. Results A link between 25(OH)D and A-CMR in the US, France, Iran and the UK (countries with similar screening status) may exist. We observed an inverse correlation (correlation coefficient ranging from -0.84 to -1) between high CRP HGNC and 25(OH)D. Age and the family income status also correlated to high CRP HGNC and subjects with higher age and lower family income presented more incidences of high CRP HGNC. Our analysis determined a possible link between high CRP HGNC and Vit D deficiency MESHD Vit D deficiency HGNC and calculated an OR of 1.8 with 95%CI (1.2 to 2.6) among the elderly (age greater than or equal to 60 yo) in low-income families and an OR of 1.9 with 95%CI (1.4 to 2.7) among the elderly (age greater than or equal to 60 yo) in high-income families. COVID-19 MESHD patient-level data shows a notable OR of 3.4 with 95%CI (2.15 to 5.4) for high CRP HGNC in severe COVID-19 MESHD patients. Conclusion Given that CRP HGNC is a surrogate marker for cytokine storm and is associated with Vit HGNC Vit MESHD D deficiency, based on retrospective data and indirect evidence we see a possible role of Vit HGNC D in reducing complications attributed to unregulated inflammation MESHD and cytokine storm. Further research is needed to account for other factors through direct measurement of Vit HGNC D levels in COVID-19 MESHD patients.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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