Corpus overview


MeSH Disease

COVID-19 (1)

HGNC Genes

SARS-CoV-2 proteins

ORF1 (1)

ProteinN (1)


SARS-CoV-2 Proteins
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    SARS-CoV-2 genome-wide mapping of CD8 HGNC T cell recognition reveals strong immunodominance and substantial CD8 HGNC T cell activation in COVID-19 MESHD patients

    Authors: Sunil Kumar Saini; Ditte Stampe Hersby; Tripti Tamhane; Helle Rus Povlsen; Susana Patricia Amaya Hernandez; Morten Nielsen; Anne Ortved Gang; Sine Reker Hadrup; Sergio Poli; Lance M. Peter; Chase J. Taylor; Jessica B. Blackburn; Bradley W. Richmond; Andrew G. Nicholson; Doris Rassl; William A. Wallace; Ivan O. Rosas; R. Gisli Jenkins; Naftali Kaminski; Jonathan A. Kropski; Nicholas E. Banovich; - Human Cell Atlas Lung Biological Network; Renata J Medeiros; Juliana MM Gomes; Mara Souza Junqueira; Katia Conceicao; Leticia G. Pontes; Antonio Condino Neto; Andrea C Perez; Leonardo G Barcellos; Jose Dias Correa Junior; Erick Gustavo Dorlass; Niels OS Camara; Edison Luiz Durigon; Fernando Q Cunha; Rafael H Nobrega; Glaucia M Machado-Santelli; Chuck S Farah; Flavio P Veras; Jorge Galindo-Villegas; Leticia Costa-Lotufo; Thiago M Cunha; Roger Chammas; Luciani R. Carvalho; Cristiane R. Guzzo; Ives Charlie-Silva

    doi:10.1101/2020.10.19.344911 Date: 2020-10-19 Source: bioRxiv

    To understand the CD8 HGNC+ T cell immunity related to viral protection and disease severity in COVID-19 MESHD, we evaluated the complete SARS-CoV-2 genome (3141 MHC-I binding peptides) to identify immunogenic T cell epitopes, and determine the level of CD8 HGNC+ T cell involvement using DNA-barcoded peptide-major histocompatibility complex (pMHC) multimers. COVID-19 MESHD patients showed strong T cell responses, with up to 25% of all CD8 HGNC+ lymphocytes specific to SARS-CoV-2-derived immunodominant epitopes, derived from ORF1 PROTEIN ( open reading frame 1 PROTEIN), ORF3 HGNC, and Nucleocapsid (N) protein PROTEIN. A strong signature of T cell activation was observed in COVID-19 MESHD patients, while no T cell activation was seen in the non-exposed and high exposure risk healthy donors. Interestingly, patients with severe disease displayed the largest T cell populations with a strong activation profile. These results will have important implications for understanding the T cell immunity to SARS-CoV-2 infection MESHD, and how T cell immunity might influence disease development.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins

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