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MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

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    Generation of Inhibitory Autoantibodies to ADAMTS13 HGNC in Coronavirus Disease 2019 MESHD

    Authors: Adrian Atilla Nicolas Doevelaar; Martin Bachmann; Bodo Hoelzer; Felix Sebastian Seibert; Benjamin Johannes Rohn; Oliver Witzke; Ulf Dittmer; Thorsten Brenner; Krystallenia Paniskaki; Serap Yilmaz; Rita Dittmer; Sonja Schneppenheim; Nina Babel; Ulrich Budde; Timm Henning Westhoff

    doi:10.1101/2021.03.18.21253869 Date: 2021-03-20 Source: medRxiv

    Objectives: It has recently been shown that von Willebrand factor HGNC von Willebrand factor MESHD ( vWf HGNC) multimers may be a key driver of immunothrombosis in Coronavirus disease MESHD Coronavirus disease 2019 MESHD ( COVID-19 MESHD). Since COVID-19 MESHD is associated with an increased risk of autoreactivity, the present study investigates, whether the generation of autoantibodies to ADAMTS13 HGNC contributes to this finding. Design: Observational prospective controlled multicenter study. Setting: Blood samples and clinical data of patients with COVID-19 MESHD were collected regularly during hospitalization in the period from April to November 2020. Patients: 90 patients with confirmed COVID-19 MESHD of mild to critical severity and 30 healthy controls participated in this study. Measuerements and Main Results: Antibodies to ADAMTS13 HGNC occurred in 31 (34.4%) patients with COVID-19 MESHD. Generation of ADAMTS13 HGNC antibodies was associated with a significantly lower ADAMTS13 HGNC activity (56.5%, interquartile range (IQR) 21.25 vs. 71.5%, IQR 24.25, p=0.0041), increased disease MESHD severity (severe or critical disease MESHD in 90% vs. 62.3%, p=0.0189), and a trend to a higher mortality (35.5% vs. 18.6%, p=0.0773). Median time to antibody development was 11 days after first positive SARS-CoV-2-PCR specimen. Conclusion: The present study demonstrates for the first time, that generation of antibodies to ADAMTS13 HGNC is a frequent finding in COVID-19 MESHD. Generation of these antibodies is associated with a lower ADAMTS13 HGNC activity and an increased risk of an adverse course of the disease suggesting an inhibitory effect on the protease. These findings provide a rationale to include ADAMTS13 HGNC antibodies in the diagnostic workup of SARS-CoV-2 infections MESHD.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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