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MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

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    Transcriptional landscape of SARS-CoV-2 infection MESHD dismantles pathogenic pathways activated by the virus, proposes unique sex-specific differences and predicts tailored therapeutic strategies

    Authors: Paolo Fagone; Rosella Ciurleo; Salvo Danilo Lombardo; Carmelo Iacobello; Concetta Ilenia Palermo; Yehuda Shoenfeld; Klaus Bendtzen; Placido Bramanti; Ferdinando Nicoletti

    id:2005.01042v1 Date: 2020-05-03 Source: arXiv

    The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease MESHD ( COVID-19 MESHD) has posed a serious threat to global health. As no specific therapeutics are yet available to control disease evolution, more in-depth understanding of the pathogenic mechanisms induced by SARS-CoV-2 will help to characterize new targets for the management of COVID-19 MESHD. The present study identified a specific set of biological pathways altered in primary human lung epithelium upon SARS-CoV-2 infection MESHD, and a comparison with SARS-CoV from the 2003 pandemic was studied. The transcriptomic profiles were also exploited as possible novel therapeutic targets, and anti-signature perturbation analysis predicted potential drugs to control disease progression. Among them, Mitogen-activated protein kinase kinase ( MEK HGNC), serine-threonine kinase ( AKT HGNC), mammalian target of rapamycin HGNC ( mTOR HGNC) and I kappa B Kinase (IKK) inhibitors emerged as candidate drugs. Finally, sex-specific differences that may underlie the higher COVID-19 MESHD mortality in men are proposed.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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