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HGNC Genes

SARS-CoV-2 proteins

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    Higher serum levels of Chemokine CCL19 HGNC are associated with poor SARS-CoV-2 acute respiratory distress syndrome (ARDS) outcomes.

    Authors: Joseph Balnis; Alejandro P Adam; Amit Chopra; Hau C Chieng; Paul J Feustel; Katherine A Overmyer; Evgenia Shishkova; Joshua J Coon; Harold A Singer; Marc A Judson; Ariel Jaitovich

    doi:10.1101/2020.05.21.20051300 Date: 2020-05-22 Source: medRxiv

    COVID19 MESHD pandemic has so far caused over three hundred thousand deaths worldwide, primarily due to complications from SARS-CoV-2-associated acute respiratory distress syndrome MESHD ( ARDS MESHD). While an ARDS MESHD-driven hyperinflammatory phenotype is associated with higher mortality in non-COVID patients, there is little information on how cytokines and chemokines expressions correlate with clinical outcomes in COVID19 MESHD patients. We prospectively enrolled a cohort of 41 patients with acute respiratory distress syndrome MESHD on mechanical ventilation. Patients blood was obtained at enrollment and outcome measures were liberation from mechanical ventilation and hospital-free days. We determined the expression levels of 44 circulating cytokines/chemokines and found 13 of them associated with worse outcomes. After correcting for multiple comparisons/false discovery rate, only one chemokine ( CCL19 HGNC) remained significantly associated with outcomes (p=0.009). Although not described in association with COVID19 MESHD, this chemokine was previously found elevated in an animal model of SARS-CoV MESHD. Moreover, CCL19 HGNC seems to be relevant for bronchus-associated lymphoid tissue (BALT) maintenance and for lung immunity to influenza virus. While this finding requires corroboration, CCL19 HGNC determination could facilitate early identification COVID19 MESHD- ARDS MESHD patients at higher risk of death MESHD and be novel target for immunotherapy in this setting.

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MeSH Disease
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SARS-CoV-2 Proteins


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