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SARS-CoV-2 proteins

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    Higher expression of monocyte chemotactic protein 1 HGNC in mild COVID-19 MESHD patients might be correlated with inhibition of Type I IFN signaling

    Authors: Xueyan Xi; Yang Guo; Min Zhu; Yuhui Wei; Gang Li; Boyu Du; Yunfu Wang

    doi:10.21203/rs.3.rs-71401/v5 Date: 2020-09-03 Source: ResearchSquare

    Background: Chemokine levels in severe coronavirus disease 2019 MESHD ( COVID-19 MESHD) patients have been shown to be markedly elevated. But the role of chemokines in mild COVID-19 MESHD has not yet been established. According to the epidemiological statistics, most of the COVID-19 MESHD cases in Shiyan City, China, have been mild. The purpose of this study was to evaluate the level of chemokines in mild COVID-19 MESHD patients and explore the correlation between chemokines and host immune response. Methods: In this study, we used an enzyme-linked immunosorbent assay (ELISA) to detect serum levels of chemokines in COVID-19 MESHD patients in Shiyan City. Expression of chemokine receptors and of other signaling molecules was measured by real-time polymerase chain reaction (PCR).  Results: We first demonstrated that COVID-19 MESHD patients, both sever and mild cases, are characterized by higher level of chemokines. Specifically, monocyte chemotactic protein 1 HGNC ( MCP-1 HGNC) is expressed at higher levels both in severe and mild cases of COVID-19 MESHD. The receptor of MCP-1 HGNC, C-C chemokine receptor type 2 HGNC ( CCR2 HGNC), was expressed at higher levels in mild COVID-19 MESHD patients. Finally, we observed a significant negative correlation between expression levels of interferon (IFN) regulatory factor 3 HGNC ( IRF3 HGNC) and serum levels of MCP-1 HGNC in mild COVID-19 MESHD patients. Conclusion: Higher expression of MCP-1 HGNC in mild COVID-19 MESHD patients might be correlated with inhibition of IFN signaling. The finding adds to our understanding of the immunopathological mechanisms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection MESHD and provides potential therapeutic targets and strategies.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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