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SARS-CoV-2 proteins

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    Strong anti-viral responses in pediatric COVID-19 MESHD patients in South Brazil

    Authors: Tiago Fazolo; Karina Lima; Julia C. Fontoura; Priscila Oliveira de Souza; Gabriel Hilario; Renata Zorzetto; Luiz Rodrigues Jr.; Veridiane Maria Pscheidt; Jayme Ferreira Neto; Alisson F. Haubert; Izza Gambin; Aline C. Oliveira; Raissa S. Mello; Matheus Gutierrez; Rodrigo Benedetti Gassen; Ivaine Tais Sauthier Sartor; Gabriela Oliveira Zavaglia; Ingrid Rodrigues Fernandes; Fernanda Hammes Varela; Márcia Polese-Bonatto; Thiago J. Borges; Sidia Maria Callegari-Jacques; Marcela Santos Correa da Costa; Jaqueline de Araujo Schwartz; Marcelo Comerlato Scotta; Renato T. Stein; Cristina Bonorino

    doi:10.1101/2021.04.13.21255139 Date: 2021-04-16 Source: medRxiv

    Epidemiological evidence that COVID-19 MESHD manifests as a milder disease in children compared to adults has been reported by numerous studies, but the mechanisms underlying this phenomenon have not been characterized. It is still unclear how frequently children get infected, and/or generate immune responses to SARS-CoV-2. We have performed immune profiling of pediatric and adult COVID-19 MESHD patients in Brazil, producing over 38 thousand data points, asking if cellular or humoral immune responses could help explain milder disease in children. In this study, pediatric COVID-19 MESHD patients presented high viral titers. Though their non-specific immune profile was dominated by naive, non-activated lymphocytes, their dendritic cells expressed high levels of HLA-DR and were low in CX3CR1 HGNC, indicating competence to generate immune responses that are not targeted to inflamed tissue. Finally, children formed strong specific antibody and T cell responses for viral structural proteins. Children s T cell responses differed from adults in that their CD8 HGNC+ TNF+ T cell responses were low for S peptide but significantly higher against N and M peptide pools. Altogether, our data support a scenario in which SARS-CoV-2 infected MESHD children may contribute to transmission, though generating strong and differential responses to the virus that might associate with protection in pediatric COVID-19 MESHD presentation.

    Deep Immune Profiling of MIS HGNC-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19 MESHD

    Authors: Laura Vella; Josephine R. Giles; Amy E. Baxter; Derek A Oldridge; Caroline Diorio; Leticia Kuri-Cervantes; Cecile Alanio; Maria Betina Pampena; Jennifer E Wu; Zeyu Chen; Yinghui Jane Huang; Elizabeth M. Anderson; Sigrid Gouma; Kevin O. McNerney; Julie Chase; Chakkapong Burudpakdee; Jessica H. Lee; Sokratis A. Apostolidis; Alexander C. Huang; Divij Mathew; Oliva Kuthuru; Eileen C. Goodwin; Madison E. Weirick; Marcus J. Bolton; Claudia P. Arevalo; Andre Ramos; Cristina Jasen; Heather M. Giannini; Kurt DAndrea; - The UPenn COVID Processing Unit; Nuala J. Meyer; Edward M. Behrens; Hamid Bassiri; Scott E. Hensley; Sarah E. Henrickson; David T. Teachey; Michael R. Betts; E. John Wherry

    doi:10.1101/2020.09.25.20201863 Date: 2020-09-27 Source: medRxiv

    Pediatric COVID-19 MESHD following SARS-CoV-2 infection MESHD is associated with fewer hospitalizations and often milder disease than in adults. A subset of children, however, present with Multisystem Inflammatory Syndrome MESHD in Children ( MIS HGNC-C) that can lead to vascular complications and shock, but rarely death MESHD. The immune features of MIS HGNC-C compared to pediatric COVID-19 MESHD or adult disease remain poorly understood. We analyzed peripheral blood immune responses in hospitalized SARS-CoV-2 infected pediatric MESHD patients (pediatric COVID-19 MESHD) and patients with MIS HGNC-C. MIS HGNC-C patients had patterns of T cell-biased lymphopenia MESHD and T cell activation similar to severely ill adults, and all patients with MIS HGNC-C had SARS-CoV-2 spike PROTEIN-specific antibodies at admission. A distinct feature of MIS HGNC-C patients was robust activation of vascular patrolling CX3CR1 HGNC+ CD8 T cells that correlated with use of vasoactive medication. Finally, whereas pediatric COVID-19 MESHD patients with acute respiratory distress syndrome MESHD ( ARDS MESHD) had sustained immune activation, MIS HGNC-C patients displayed clinical improvement over time, concomitant with decreasing immune activation. Thus, non- MIS HGNC-C versus MIS HGNC-C SARS-CoV-2 associated illnesses are characterized by divergent immune signatures that are temporally distinct and implicate CD8 T cells in clinical presentation and trajectory of MIS HGNC-C.

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MeSH Disease
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SARS-CoV-2 Proteins


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