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SARS-CoV-2 proteins

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    Switched and unswitched memory B cells detected during SARS-CoV-2 convalescence correlate with limited symptom duration

    Authors: Krista L Newell; Deanna C Clemmer; Justin B Cox; Yetunde I Kayode; Victoria Zoccoli-Rodriguez; Harry E Taylor; Timothy P Endy; Joel R Wilmore; Gary Winslow

    doi:10.1101/2020.09.04.20187724 Date: 2020-09-05 Source: medRxiv

    Severe acute respiratory syndrome coronavirus-2 MESHD (SARS-CoV-2), the causative agent of the pandemic human respiratory illness COVID-19 MESHD, is a global health emergency. While severe acute disease MESHD has been linked to an expansion of antibody-secreting plasmablasts, we sought to identify B cell responses that correlated with positive clinical outcomes in convalescent patients. We characterized the peripheral blood B cell immunophenotype and plasma antibody responses in 40 recovered non-hospitalized COVID-19 MESHD subjects that were enrolled as donors in a convalescent plasma treatment study. We observed a significant negative correlation between the frequency of peripheral blood memory B cells and the duration of symptoms for convalescent subjects. Memory B cell subsets in convalescent subjects were composed of classical CD24 HGNC+ class-switched memory B cells, but also activated CD24 HGNC-negative and natural unswitched CD27 HGNC+ IgD+ IgM+ subsets. Memory B cell frequency was significantly correlated with both IgG1 and IgM responses to the SARS-CoV-2 spike PROTEIN protein receptor binding domain (RBD). IgM+ memory, but not switched memory, directly correlated with virus-specific antibody responses, and remained stable over time. Our findings suggest that the frequency of memory B cells is a critical indicator of disease resolution, and that IgM+ memory B cells play an important role in SARS-CoV-2 immunity.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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