Corpus overview


Overview

MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

There are no SARS-CoV-2 protein terms in the subcorpus


Filter

Genes
Diseases
SARS-CoV-2 Proteins
    displaying 1 - 1 records in total 1
    records per page




    Systematic review and meta-analysis identifies potential host therapeutic targets in COVID-19 MESHD.

    Authors: Nicholas Parkinson; Natasha Rodgers; Max Head Fourman; Bo Wang; Marie Zechner; Maaike Swets; Jonathan E Millar; Andy Law; Clark Russell; J Kenneth Baillie; Sara Clohisey

    doi:10.1101/2020.08.27.20182238 Date: 2020-09-01 Source: medRxiv

    An increasing body of literature describes the role of host factors in COVID-19 MESHD pathogenesis. There is a need to combine diverse, multi-omic data in order to evaluate and substantiate the most robust evidence and inform development of future therapies. We conducted a systematic review of experiments identifying host factors involved in human betacoronavirus infection (SARS-CoV-2, SARS-CoV MESHD, MERS-CoV, seasonal coronaviruses). Gene lists from these diverse sources were integrated using Meta-Analysis by Information Content (MAIC). This previously described algorithm uses data-driven gene list weightings to produce a comprehensive ranked list of implicated host genes. 5,418 genes implicated in human betacoronavirus infection MESHD were identified from 32 datasets. The top ranked gene was *PPIA*, encoding cyclophilin A. Pharmacological inhibition with cyclosporine in vitro exerts antiviral activity against several coronaviruses including SARS-CoV MESHD. Other highly-ranked genes included proposed prognostic factors (* CXCL10 HGNC*, *CD4*, * CD3E HGNC*) and investigational therapeutic targets (* IL1A HGNC*) for COVID-19 MESHD, but also previously overlooked genes with potential as therapeutic targets. Gene rankings also inform the interpretation of COVID-19 MESHD GWAS results, implicating * FYCO1 HGNC* over other nearby genes in a disease-associated locus on chromosome 3. Pathways enriched in gene rankings included T-cell receptor signalling, protein processing, and viral infections MESHD. We identified limited overlap of our gene list with host genes implicated in ARDS (innate immune and inflammation MESHD genes) and Influenza A virus infection MESHD (RNA-binding and ribosome-associated genes). We will continue to update this dynamic ranked list of host genes as the field develops, as a resource to inform and prioritise future studies. Updated results are available at https://baillielab.net/maic/ covid19 MESHD.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).
The web page can also be accessed via API.

Sources


Annotations

All
None
MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


Export subcorpus as...

This service is developed in the project nfdi4health task force covid-19 which is a part of nfdi4health.

nfdi4health is one of the funded consortia of the National Research Data Infrastructure programme of the DFG.