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MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

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    CD47 HGNC as a potential biomarker for the early diagnosis of severe COVID-19 MESHD

    Authors: Katie-May McLaughlin; Denisa Bojkova; Marco Bechtel; Joshua Kandler; Philipp Reus; Trang Le; Julian UG Wagner; Sandra Ciesek; Mark N Wass; Martin Michaelis; Jindrich N Cinatl Jr.

    doi:10.1101/2021.03.01.433404 Date: 2021-03-01 Source: bioRxiv

    The coronavirus SARS-CoV-2 is the cause of the ongoing COVID-19 pandemic MESHD. Most SARS-CoV-2 infections MESHD SARS-CoV-2 infections MESHD are mild or even asymptomatic. However, a small fraction of infected MESHD individuals develops severe, life-threatening disease, which is caused by an uncontrolled immune response resulting in hyperinflammation. Antiviral interventions are only effective prior to the onset of hyperinflammation. Hence, biomarkers are needed for the early identification and treatment of high-risk patients. Here, we show in a range of model systems and data from post mortem samples that SARS-CoV-2 infection MESHD results in increased levels of CD47 HGNC, which is known to mediate immune escape in cancer MESHD and virus-infected cells. Systematic literature searches also indicated that known risk factors such as older age and diabetes MESHD are associated with increased CD47 HGNC levels. High CD47 HGNC levels contribute to vascular disease MESHD, vasoconstriction, and hypertension MESHD, conditions which may predispose SARS-CoV-2-infected MESHD individuals to COVID-19 MESHD-related complications such as pulmonary hypertension MESHD, lung fibrosis MESHD, myocardial injury MESHD, stroke MESHD, and acute kidney injury MESHD. Hence, CD47 HGNC is a candidate biomarker for severe COVID-19 MESHD. Further research will have to show whether CD47 HGNC is a reliable diagnostic marker for the early identification of COVID-19 MESHD patients requiring antiviral therapy.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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