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SARS-CoV-2 proteins

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    Molecular Phenomics of Gut Ecosystem in COVID-19 MESHD Patients 

    Authors: Zhixiang Yan; Feixiang He; Huanhuan He; Dan Li; Pengfei Pang; Zhaoxiong Fang; Guanmin Jiang; Siwen Huang; Kexue Li; Zhiqiang Gu; Honggang Shi; Zhenyi Zhang; Huijin Zhu; Lu Lin; Jialin Li; Ru Yan; Fei Xiao; Xiaofeng Li; Hong Shan

    doi:10.21203/rs.3.rs-208797/v1 Date: 2021-02-04 Source: ResearchSquare

    Background: Gut ecosystem has profound effects on host physiology and health. Gastrointestinal (G I) MESHD symptoms were frequently observed in patients with COVID-19 MESHD. Compared with other organs, gut antiviral response can result in more complicated immune responses because of the interactions between the gut microbiota and host immunity. However, there are still large knowledge gaps in the impact of COVID-19 MESHD on gut molecular profiles and commensal microbiome, hindering our comprehensive understanding of the pathogenesis of S ARS-CoV-2 MESHDand the treatment of COVID-19 MESHD.Results: We performed longitudinal stool multi-omics profiling to systemically investigate the molecular phenomics alterations of gut ecosystem in COVID-19 MESHD. Gut proteomes of COVID-19 MESHD were characterized by disturbed immune, proteolysis and redox homeostasis. The expression and glycosylation of proteins involved in neutrophil degranulation and migration were suppressed, while those of proteases were upregulated. The variable domains of Ig heavy chains were downregulated and the overall glycosylation of IgA heavy chain constant regions, I gGFc-binding protein, HGNC and J chain were suppressed with glycan-specific variations. There was a reduction of beneficial gut bacteria and an enrichment of bacteria derived deleterious metabolites potentially associated with multiple types of diseases (such as ethyl glucuronide). The reduction of Ig heave chain variable domains may contribute to the increase of some Bacteroidetes species. Many bacteria ceramide lipids with a C17-sphingoid based were downregulated in COVID-19 MESHD. In many cases, the gut phenome did not restore two months after symptom onset.Conclusions: Our study indicates widely disturbed gut molecular profiles which may play a role in the development of symptoms in COVID-19 MESHD. Our findings also emphasis the need for ongoing investigation of the long-term gut molecular and microbial alterations during COVID-19 MESHD recovery process. Considering the gut ecosystem as a potential target could offer a valuable approach in managing the disease.

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MeSH Disease
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SARS-CoV-2 Proteins


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