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SARS-CoV-2 proteins

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    Durable SARS-CoV-2 B cell immunity after mild or severe disease

    Authors: Clinton O. Ogega; Nicole E. Skinner; Paul W Blair; Han-Sol Park; Kirsten Littlefield; Abhinaya Ganesan; Pranay Ladiwala; Annukka AR Antar; Stuart C. Ray; Michael J. Betenbaugh; Andrew Pekosz; Sabra Klein; Yukari C Manabe; Andrea L. Cox; Justin R. Bailey

    doi:10.1101/2020.10.28.20220996 Date: 2020-10-30 Source: medRxiv

    Multiple studies have shown loss of SARS-CoV-2 specific antibodies over time after infection, raising concern that humoral immunity against the virus is not durable. If immunity wanes quickly, millions of people may be at risk for reinfection after recovery from COVID-19 MESHD. However, memory B cells ( MBC MESHD) could provide durable humoral immunity even if serum neutralizing antibody titers decline. We performed multi-dimensional flow cytometric analysis of S protein PROTEIN receptor binding domain (S-RBD)-specific MBC MESHD in cohorts of ambulatory COVID-19 MESHD patients with mild disease, and hospitalized patients with moderate to severe disease, at a median of 54 (39-104) days after onset of symptoms. We detected S-RBD-specific class-switched MBC MESHD in 13 out of 14 participants, including 4 of the 5 participants with lowest plasma levels of anti-S-RBD IgG and neutralizing antibodies. Resting MBC MESHD (rMBC) made up the largest proportion of S-RBD-specific class-switched MBC MESHD in both cohorts. FCRL5 HGNC, a marker of functional memory when expressed on rMBC, was dramatically upregulated on S-RBD-specific rMBC. These data indicate that most SARS-CoV-2-infected MESHD individuals develop S-RBD-specific, class-switched MBC MESHD that phenotypically resemble germinal center-derived B cells induced by effective vaccination against other pathogens, providing evidence for durable B cell-mediated immunity against SARS-CoV-2 after recovery from mild or severe COVID-19 MESHD disease.

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MeSH Disease
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