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HGNC Genes

SARS-CoV-2 proteins

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    SARS-CoV-2 infection MESHD reduces Krüppel-Like Factor 2 HGNC in human lung autopsy MESHD

    Authors: Tzu-Han Lee; David Wu; Robert Guzy; Nathan Schoettler; Ayodeji Adegunsoye; Jeffrey Mueller; Aliya Hussein; Anne Sperling; Gokhan M Mutlu; Yun Fang

    doi:10.1101/2021.01.15.426691 Date: 2021-01-18 Source: bioRxiv

    Acute respiratory distress syndrome ( ARDS MESHD) occurred in ~12% of hospitalized COVID-19 MESHD patients in a recent New York City cohort. Pulmonary endothelial dysfunction MESHD, characterized by increased expression of inflammatory genes and increased monolayer permeability, is a major component of ARDS. Vascular leak results in parenchymal accumulation of leukocytes, protein, and extravascular water, leading to pulmonary edema MESHD, ischemia MESHD, and activation of coagulation associated with COVID-19 MESHD. Endothelial inflammation MESHD further contributes to uncontrolled cytokine storm in ARDS. We have recently demonstrated that Kruppel-like factor 2 HGNC ( KLF2 HGNC), a transcription factor which promotes endothelial quiescence and monolayer integrity, is significantly reduced in experimental models of ARDS. Lung inflammation MESHD and high-tidal volume ventilation result in reduced KLF2 HGNC, leading to pulmonary endothelial dysfunction MESHD and acute lung injury MESHD. Mechanistically, we found that KLF2 HGNC is a potent transcriptional activator of Rap guanine nucleotide exchange factor 3 HGNC ( RAPGEF3 HGNC) which orchestrates and maintains vascular integrity. Moreover, KLF2 HGNC regulates multiple genome-wide association study (GWAS)-implicated ARDS genes. Whether lung KLF2 HGNC is regulated by SARS-CoV-2 infection MESHD is unknown. Here we report that endothelial KLF2 HGNC is significantly reduced in human lung autopsies from COVID-19 MESHD patients, which supports that ARDS due to SARS-CoV-2 is a vascular phenotype possibly attributed to KLF2 HGNC down-regulation. We provide additional data demonstrating that KLF2 is down-regulated in SARS-CoV infection MESHD in mice.

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MeSH Disease
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SARS-CoV-2 Proteins


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