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MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

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    Growth factor receptor signaling inhibition prevents SARS-CoV-2 replication

    Authors: Kevin Klann; Denisa Bojkova; Georg Tascher; Sandra Ciesek; Christian Muench; Jindrich Cinatl

    doi:10.1101/2020.05.14.095661 Date: 2020-05-14 Source: bioRxiv

    SARS-CoV-2 infections MESHD SARS-CoV-2 infections MESHD are rapidly spreading around the globe. The rapid development of therapies is of major importance. However, our lack of understanding of the molecular processes and host cell signaling events underlying SARS-CoV-2 infection MESHD hinder therapy development. We employed a SARS-CoV-2 infection MESHD system in permissible human cells to study signaling changes by phospho-proteomics. We identified viral protein phosphorylation and defined phosphorylation-driven host cell signaling changes upon infection. Growth factor receptor ( GFR HGNC) signaling and downstream pathways were activated. Drug-protein network analyses revealed GFR HGNC signaling as key pathway targetable by approved drugs. Inhibition of GFR HGNC downstream signaling by five compounds prevented SARS-CoV-2 replication in cells, assessed by cytopathic effect, viral dsRNA production, and viral RNA release into the supernatant. This study describes host cell signaling events upon SARS-CoV-2 infection MESHD and reveals GFR HGNC signaling as central pathway essential for SARS-CoV-2 replication. It provides with novel strategies for COVID-19 MESHD treatment.

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MeSH Disease
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SARS-CoV-2 Proteins


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