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SARS-CoV-2 proteins

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    Comparative Analysis of Clinical Characteristics in Children and Adults with 2019 Novel Coronavirus Infection MESHD: A Descriptive Study

    Authors: Ya-nan Han; Zhan-wei Feng; Li-na Sun; Xiao-xia Ren; Hua Wang; Yong-ming Xue; Yi Wang; Ying Fang

    doi:10.21203/rs.3.rs-17872/v1 Date: 2020-03-17 Source: ResearchSquare

    Background: Since December 2019, acute respiratory disease MESHD ( ARD MESHD ARD HGNC) caused by 2019 novel coronavirus (2019-nCoV) rapidly spread throughout China. Children and adults seemed to differ in the clinical course of the disease. The purpose of the current study is to comparatively analyze the clinical characteristics of children and adult patients with 2019-nCoV infection MESHD and to explore the possible causes for the discrepant aspects.Methods: In this retrospective study, the medical records of 32 cases confirmed with 2019-nCoV ARD MESHD ARD HGNC from Xi'an eighth hospital (Shaanxi, China) from January 31 to February 16, 2020 were reviewed.Results: In all 32 patients contained 7 children and 25 adults. All children were family cluster. For adult patients, local residents of Wuhan, recently travelled to Wuhan, patient contacted with people from Wuhan were 14 (56%), 10 (40%), 1 (4%), respectively. The median incubation period of children and adult was 5 days (range, 3 to 12) and 4 days (range, 2 to 12), respectively. Altogether 10 (40%) adult patients had underlying conditions significantly, but no children had. Fever MESHD (Children 71.4% vs. Adult 96%) and cough (Children 71.4% vs. Adult 76%) were the most common symptoms in both groups. The third symptom observed in children was diarrhea MESHD and/or vomiting MESHD (57.1%), for adult it was myalgia MESHD or fatigue MESHD (52%). On admission, 5 (71.4%) children patients showed pneumonia MESHD roughly the same as adult patients (20, 80%), and that the two group shared a multitude of common imaging characteristics. 20% of adult with leucopoenia, but leukocytosis MESHD was significantly more frequently in children (28.6%, P=0.014). More children had elevated creatine kinase isoenzyme (57.1% vs. 4%, P=0.004). All patients were discharged after symptomatic treatment, including oxygen therapy, antiviral treatment, antibiotic treatment. Only one infant was intravenously injected low-dose glucocorticoids.Conclusions: Our results multi-dimensionally demonstrate that children with 2019-nCoV infection MESHD present a clinical picture which is often distinct from that of adults. Knowledge of these differences will be helpful for the clinical diagnosis of 2019 novel coronavirus disease MESHD coronavirus diseases MESHD ( COVID-19 MESHD) and for a future discussion on age specific infection case definitions.

    Clinical characteristics of 2019 novel coronavirus infection MESHD in China

    Authors: Wei-jie Guan; Zheng-yi Ni; Yu Hu; Wen-hua Liang; Chun-quan Ou; Jian-xing He; Lei Liu; Hong Shan; Chun-liang Lei; David SC Hui; Bin Du; Lan-juan Li; Guang Zeng; Kowk-Yung Yuen; Ru-chong Chen; Chun-li Tang; Tao Wang; Ping-yan Chen; Jie Xiang; Shi-yue Li; Jin-lin Wang; Zi-jing Liang; Yi-xiang Peng; Li Wei; Yong Liu; Ya-hua Hu; Peng Peng; Jian-ming Wang; Ji-yang Liu; Zhong Chen; Gang Li; Zhi-jian Zheng; Shao-qin Qiu; Jie Luo; Chang-jiang Ye; Shao-yong Zhu; Nan-shan Zhong

    doi:10.1101/2020.02.06.20020974 Date: 2020-02-09 Source: medRxiv

    Background: Since December 2019, acute respiratory disease MESHD ( ARD MESHD ARD HGNC) due to 2019 novel coronavirus (2019-nCoV) emerged in Wuhan city and rapidly spread throughout China. We sought to delineate the clinical characteristics of these cases. Methods: We extracted the data on 1,099 patients with laboratory-confirmed 2019-nCoV ARD HGNC ARD MESHD from 552 hospitals in 31 provinces/provincial municipalities through January 29th, 2020. Results: The median age was 47.0 years, and 41.90% were females. Only 1.18% of patients had a direct contact with wildlife, whereas 31.30% had been to Wuhan and 71.80% had contacted with people from Wuhan. Fever MESHD (87.9%) and cough (67.7%) were the most common symptoms. Diarrhea MESHD is uncommon. The median incubation period was 3.0 days (range, 0 to 24.0 days). On admission, ground-glass opacity was the typical radiological finding on chest computed tomography (50.00%). Significantly more severe cases were diagnosed by symptoms plus reverse-transcriptase polymerase-chain-reaction without abnormal radiological findings than non-severe cases (23.87% vs. 5.20%, P<0.001). Lymphopenia MESHD was observed in 82.1% of patients. 55 patients (5.00%) were admitted to intensive care unit and 15 (1.36%) succumbed. Severe pneumonia MESHD was independently associated with either the admission to intensive care unit, mechanical ventilation, or death MESHD in multivariate competing-risk model (sub-distribution hazards ratio, 9.80; 95% confidence interval, 4.06 to 23.67). Conclusions: The 2019-nCoV epidemic spreads rapidly by human-to-human transmission. Normal radiologic findings are present among some patients with 2019-nCoV infection MESHD. The disease severity (including oxygen saturation, respiratory rate, blood leukocyte/lymphocyte count and chest X-ray/CT manifestations) predict poor clinical outcomes.

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MeSH Disease
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SARS-CoV-2 Proteins


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