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MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

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    Identification of SARS-CoV-2-specific immune alterations in acutely ill patients

    Authors: Rose-Marie Rebillard; Marc Charabati; Camille Grasmuck; Abdelali Filali-Mouhim; Olivier Tastet; Nathalie Brassard; Audrey Daigneault; Lyne Bourbonniere; Renaud Balthazard; Ana Carmena Moratalla; Yves Carpentier Solorio; Negar Farzam-kia; Antoine Philippe Fournier; Elizabeth Gowing; Helene Jamann; Florent Lemaitre; Victoria Hannah Mamane; Karine Thai; Jean-Franois Cailhier; Nicolas Chomont; Andres Finzi; Michael Chasse; Madeleine Durand; Nathalie Arbour; Daniel E Kaufmann; Alexandre Prat; Catherine Larochelle

    doi:10.1101/2020.12.21.20248642 Date: 2020-12-22 Source: medRxiv

    Dysregulated immune profiles have been described in symptomatic SARS-CoV-2-infected MESHD patients. Whether the reported immune alterations are specific to SARS-CoV-2 infection MESHD or also triggered by other acute illnesses remains unclear. We performed flow cytometry analysis on fresh peripheral blood from a consecutive cohort of i) patients hospitalized with acute SARS-CoV-2 infection MESHD; ii) patients of comparable age/sex hospitalized for other acute disease MESHD (SARS-CoV-2 negative); and iii) healthy controls. Using both data-driven and hypothesis-driven analyses, we found several dysregulations in immune cell subsets (e.g. decreased proportion of T cells) that are similarly associated with acute SARS-CoV-2 infection MESHD and non- COVID-19 MESHD related acute illnesses. In contrast, we identified specific differences in myeloid and lymphocyte subsets that are associated with SARS-CoV-2 status (e.g. elevated proportion of ICAM-1 HGNC+ mature/activated neutrophils, ALCAM HGNC+ monocytes, and CD38 HGNC+CD8+ T cells). A subset of SARS-CoV-2-specific immune alterations correlated with disease severity, disease outcome at 30 days and mortality. Our data provides novel understanding of the immune dysregulation that are specifically associated with SARS-CoV-2 infection MESHD among acute care hospitalized patients. Our study lays the foundation for the development of specific biomarkers to stratify SARS-CoV-2+ patients at risk of unfavorable outcome and uncover novel candidate molecules to investigate from a therapeutic perspective.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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