Corpus overview


MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

There are no SARS-CoV-2 protein terms in the subcorpus


SARS-CoV-2 Proteins
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    Authors: Emel Akgun; Mete B Tuzuner; Betul Sahin; Meltem Kilercik; Canan Kulah; Hacer N Cakiroglu; Mustafa Serteser; Ibrahim Unsal; Ahmet T Baykal

    doi:10.1101/2020.05.14.20102558 Date: 2020-05-18 Source: medRxiv

    COVID-19 MESHD or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appeared throughout the World and currently affected more than 3.6 million people and caused the death of around 252,000 people. The novel strain of the coronavirus disease MESHD is transmittable at a devastating rate with a high rate of severe hospitalization even more so for the elderly population. Currently around 50,000 patients are in a seriously critical situation. Although 1.2 million patients recovered from the disease there are still more than 2.1 Million active cases. Naso-oro-pharyngeal swab samples as the first step towards detecting suspected infection of SARS-CoV-2 MESHD provides a non-invasive method for PCR testing at a high confidence rate. Furthermore, proteomics analysis of PCR positive and negative naso-oropharyngeal samples provides information on the molecular level which highlights disease pathology. Samples from 15 PCR positive cases and 15 PCR negative cases were analyzed with nanoLC-MS/MS to identify the differentially expressed proteins. Proteomic analyses identified 207 proteins across the sample set and 17 of them were statistically significant. Protein-protein interaction analyses emphasized pathways like Neutrophil degranulation, Innate Immune System, Antimicrobial Peptides. Neutrophil Elastase HGNC ( ELANE HGNC), Azurocidin HGNC ( AZU1 HGNC), Myeloperoxidase HGNC ( MPO HGNC), Myeloblastin HGNC ( PRTN3 HGNC), Cathepsin G HGNC ( CTSG HGNC) and Transcobalamine-1 ( TCN1 HGNC) were found to be significantly altered in naso-oropharyngeal samples of SARS-CoV-2 patients. The identified proteins are linked to alteration in the innate immune system specifically via neutrophil degranulation and NETosis.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins

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