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SARS-CoV-2 proteins

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    Scouting the Receptor Binding Domain of COVID-19 MESHD: A Comprehensive Immunoinformatics Inquisition

    Authors: Zaira Rehman; Ammad Fahim; Muhammad Faraz Bhatti

    doi:10.21203/rs.3.rs-25501/v1 Date: 2020-04-26 Source: ResearchSquare

    The December of 2019 witnessed emergence of worldwide outbreak by a novel strain of coronavirus termed COVID-19 MESHD with sequence similarity of overall 96.2% with BatCoV RaTG13 (coronavirus isolated from bat) and 94% sequence identity with  Severe Acute respiratory syndrome Virus (SARS-CoV MESHD) that resulted in outbreak in 2002-2003. There is no therapeutic or preventive strategy like vaccine developed so far to overcome infection.The receptor binding domain (RBD) of COVID-19 MESHD for any potential vaccine epitopes were explored. The structure of RBD of COVID-19 MESHD, BatCoV RaTG13 and bACE2 HGNC were chalked through homology modeling followed by molecular docking and structural validation. A comprehensive immunoinformatics approach mapped conserved peptide sequence on COVID-19 MESHD RBD for their B-, Helper T- & Cytotoxic T-cell epitope profile. The recognized epitopes were further studied and validated for their docking interaction with MHC-I and MHC-II alleles. Through immune-informatics approaches the study identified conserved B- and T-cell epitopes in RBD. The B-cell epitopes lying within the receptor binding motif, LFRKSN and SYGFQPT l were found to be highly antigenic. Among T-cell epitopes, the epitope CVADYSVLY and FTNVYADSF were antigenic and exhibited affinity for maximum number of MHC-I alleles. The T cell epitopes YRLFRKSNL, VYAWNRKRI displayed affinity for maximum number of MHC-II alleles. The docking analysis of the epitopes with MHC proteins revealed strong interactions of T-cell epitopes with MHC-I and MHC-II alleles. The overlapping epitope among B- and T-cells was YRLFRKSNL. The deployment of these epitopes in potential vaccine against COVID-19 MESHD may help in sweeping the COVID-19 MESHD infectious spread. 

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MeSH Disease
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SARS-CoV-2 Proteins


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