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HGNC Genes

SARS-CoV-2 proteins

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    Involvement of Bradykinin HGNC and Folate receptor in calming the SARS-COV2 cytokine storm: Lessons learnt from lung cancer

    Authors: Pruthvi Gowda; Ellora Sen

    doi:10.21203/rs.3.rs-23656/v1 Date: 2020-04-17 Source: ResearchSquare

    Background: Severe acute respiratory syndrome MESHD coronavirus (SARS-CoV2) is a highly pathogenic respiratory virus that causes morbidity and mortality in humans. The lungs are the major pathological target of SARS-CoV infection MESHD. The pathological derangements, aberrant signalling and dysregulated inflammation MESHD characteristics of lung cancer MESHD have marked similarities with the clinical manifestation of SARS-COV2 infection MESHD. As heightened inflammatory response is a key feature of both SARS-CoV infection and lung cancer MESHD and given the intriguing commonalities between the two, we analysed the RNA sequence dataset from lung cancer MESHD patients to get a better understanding of the critical regulators of inflammation MESHD in SAR-COV2. Methods: The Cancer Genome Atlas (TCGA) data sets of lung cancer MESHD were analyzed for correlations between ACE2 HGNC, Bradykinin HGNC, and other genes associated with inflammatory responses.Results: TCGA dataset analysis indicated an inverse correlation between ACE2 HGNC and Bradykinin Receptor 1 HGNC ( BDKRB1 HGNC), IL-6 HGNC and IFNg HGNC in lung adenocarcinoma. A positive correlation between EGF, FOLR1 HGNC, MAOA HGNC, NOSTRIN HGNC, MARC2 HGNC, PHKD1, and ACE2 HGNC was noted Summary: Our analysis has identified a common (i) ACE2 HGNC- BDKRB1 HGNC-inflammatory network and (ii) FOLR1 HGNC-Nitric oxide cross-talk in lung cancer MESHD and SARS-CoV2. Better understanding of the convergences between critical players in these networks would enable efficient repurposing of approved lung cancer MESHD therapeutics for COVID-19 MESHD infection. 

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MeSH Disease
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