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MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

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    The aging whole blood transcriptome reveals a potential role of FASLG HGNC in COVID-19 MESHD

    Authors: Luiz Gustavo Chuffa Sr.; Jeferson dos Santos Souza Sr.; Mariana Costa de Mello; Mario de Oliveira Neto Sr.; Robson Francisco Carvalho Sr.; Kevin S. Cashman; Richard P. Ramonell; Shuya Kyu; Ankur Singh Saini; Monica Cabrera-Mora; Andrew Derrico; David Alter; John D. Roback; Michael Horwath; Henry M. Wu; An-Kwok Ian Wong; Alexandra W. Dretler; Ria Gripaldo; Andrea N. Lane; Hao Wu; Saeyun Lee; Mindy Hernandez; Vanessa Engineer; John Varghese; Sang Le; Iñaki Sanz; John L. Daiss; Frances Eun-Hyung Lee

    doi:10.1101/2020.12.04.412494 Date: 2020-12-06 Source: bioRxiv

    The risk for severe illness from COVID-19 MESHD increases with age as older patients are at the highest risk. Although it is still unclear whether the virus is blood-transmitted, the viral RNA is detected in serum. Identifying how Severe Acute Respiratory Syndrome Coronavirus 2 MESHD (SARS-CoV-2) interacts with specific blood components during aging is expected to guide proper therapies. Considering that all human coronavirus require host cellular molecules to promote infection, we investigated the aging whole blood transcriptome from the Genotype-Tissue Expression (GTEx) database to explore differentially expressed genes (DEGs) translated into proteins potentially interacting with viral proteins. From a total of 22 DEGs in aged blood, five genes ( FASLG HGNC, CTSW HGNC, CTSE HGNC, VCAM1 HGNC, and BAG3 HGNC) changed expression during aging. These age-related genes are involved in immune response, inflammation MESHD, cell component and cell adhesion, and platelet activation/aggregation. Both males and females older than 50 overexpress FASLG HGNC compared with younger adults (20-30 years old), possibly inducing a hyper-inflammatory cascade that activates specific immune cells. Furthermore, the expression of cathepsins ( CTSW HGNC and CTSE HGNC) and the anti-apoptotic co-chaperone molecule BAG3 HGNC was significantly increased throughout aging in both gender. By exploring publicly available Single-Cell RNA-Sequencing (scRNA-Seq) data on peripheral blood of SARS-CoV-2-infected MESHD patients, we found FASLG HGNC and CTSW HGNC expressed mainly in natural killer (NK) cells and CD8+ (cytotoxic) T lymphocytes whereas BAG3 HGNC was expressed in CD4+ T cells, naive T cells, and CD14 HGNC+ monocytes. The increased expression of FASLG HGNC in blood during aging may explain why older patients are more prone to severe acute viral infection complications MESHD. These results indicate FASLG HGNC as a prognostic candidate and potential therapeutic target for more aggressive clinical manifestation of COVID-19 MESHD.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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