Corpus overview


MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

ProteinS (1)


SARS-CoV-2 Proteins
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    COVID-19 MESHD and Cholinergic Anti-inflammatory Pathway: In silico Identification of an Interaction between alpha7 Nicotinic Acetylcholine Receptor HGNC and the Cryptic Epitopes of SARS-CoV and SARS-CoV-2 Spike PROTEIN Glycoproteins

    Authors: George Lagoumintzis; Christos Chasapis; Nikolaos Alexandris; Socrates Tzartos; Elias Eliopoulos; Konstantinos Farsalinos; Konstantinos Poulas; Richard J. DiPaolo; James D Brien; Amelia K Pinto; Lei Tong; Han Xia; Jingzhe Pan; Natalie Garton; Manish Pareek; Michael Barer; Craig J Smith; Stuart M Allan; Michelle M. Lister; Hannah C. Howson-Wells; Edward C Holmes; Matthew W. Loose; Jonathan K. Ball; C. Patrick McClure; - The COVID-19 Genomics UK consortium study group; Shi Chen

    doi:10.1101/2020.08.20.259747 Date: 2020-08-21 Source: bioRxiv

    SARS-CoV-2 is the coronavirus that originated in Wuhan in December 2019 and has spread globally. The observation of a low prevalence of smokers among hospitalized COVID-19 MESHD patients has led to the development of a hypothesis that nicotine could have protective effects by enhancing the cholinergic anti-inflammatory pathway. Based on clinical data and on modelling and docking experiments we have previously presented the potential interaction between SARS-CoV-2 Spike PROTEIN SARS-CoV-2 Spike MESHD glycoprotein and nicotinic acetylcholine receptors (nAChRs), due to a "toxin-like" epitope on the Spike Glycoprotein PROTEIN, with homology to a sequence of a snake venom toxin. We here present that this epitope coincides with the well-described cryptic epitope for the human antibody CR3022 and with the epitope for the recently described COVA1 HGNC-16 antibody. Both antibodies are recognizing neighboring epitopes, are not interfering with the ACE2 HGNC protein and are not able to inhibit SARS-CoV and SARS-CoV-2 infections MESHD SARS-CoV-2 infection MESHDs. In this study we present the molecular complexes of both SARS-CoV and SARS-CoV-2 Spike MESHD SARS-CoV-2 Spike PROTEIN Glycoproteins, at their open or closed conformations, with the molecular model of the human 7 nAChR. We found that the interface of all studied protein complexes involves a large part of the "toxin-like" sequences of SARS-CoV and SARS-CoV-2 Spike MESHD SARS-CoV-2 Spike PROTEIN glycoproteins and toxin binding site of human 7 nAChR.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins

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