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SARS-CoV-2 proteins

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    A single intranasal dose of chimpanzee adenovirus-vectored vaccine confers sterilizing immunity against SARS-CoV-2 infection MESHD

    Authors: Ahmed O Hassan; Natasha M Kafai; Igor P Dmitriev; Julie M Fox; Brittany Smith; Ian B Harvey; Rita E Chen; Emma S Winkler; Alex W Wessel; James Brett Case; Elena Kashentseva; Broc T McCune; Adam L Bailey; Haiyan Zhao; Laura A VanBlargan; Yanan Dai; Meisheng Ma; Lucas J Adams; Swathi Shrihari; Lisa E Gralinski; Yixuan J Hou; Alexandra Schaefer; Arthur S Kim; Shamus P Keeler; Daniela Weiskopf; Ralph S Baric; Michael J Holtzman; Daved H Fremont; David T Curiel; Michael S Diamond

    doi:10.1101/2020.07.16.205088 Date: 2020-07-17 Source: bioRxiv

    The Coronavirus Disease 2019 MESHD pandemic has made deployment of an effective vaccine a global health priority. We evaluated the protective activity of a chimpanzee adenovirus-vectored vaccine encoding a pre-fusion stabilized spike protein PROTEIN ( ChAd HGNC ChAd MESHD-SARS-CoV-2-S) in challenge studies with Severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) and mice expressing the human angiotensin-converting enzyme 2 receptor. Intramuscular dosing of ChAd-SARS-CoV-2-S MESHD ChAd-SARS-CoV-2-S HGNC induces robust systemic humoral and cell-mediated immune responses and protects against lung infection MESHD, inflammation MESHD, and pathology but does not confer sterilizing immunity, as evidenced by detection of viral RNA and induction of anti- nucleoprotein PROTEIN antibodies after SARS-CoV-2 challenge. In contrast, a single intranasal dose of ChAd HGNC-SARS-CoV-2-S induces high levels of systemic and mucosal IgA and T cell responses, completely prevents SARS-CoV-2 infection MESHD in the upper and lower respiratory tracts, and likely confers sterilizing immunity in most animals. Intranasal administration of ChAd HGNC ChAd MESHD-SARS-CoV-2-S is a candidate for preventing SARS-CoV-2 infection MESHD and transmission, and curtailing pandemic spread.

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MeSH Disease
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SARS-CoV-2 Proteins


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