Corpus overview


MeSH Disease

HGNC Genes

SARS-CoV-2 proteins


SARS-CoV-2 Proteins
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    Identifying risk factors for COVID-19 MESHD severity and mortality in the UK Biobank MESHD

    Authors: Iqbal Madakkatel; Catherine King; Ang Zhou; Anwar Mulugeta; Amanda Lumsden; Mark McDonnell; Elina Hypponen

    doi:10.1101/2021.05.10.21256935 Date: 2021-05-11 Source: medRxiv

    Severe acute respiratory syndrome coronavirus has infected over 114 million people worldwide as of March 2021, with worldwide mortality rates ranging between 1-10%. We use information on up to 421,111 UK Biobank participants to identify possible predictors for long-term susceptibility to severe COVID-19 infection MESHD (N =1,088) and mortality (N =376). We include 36,168 predictors in our analyses and use a gradient boosting decision tree (GBDT) algorithm and feature attribution based on Shapley values, together with traditional epidemiological approaches to identify possible risk factors. Our analyses show associations between socio-demographic factors (e.g. age, sex, ethnicity, education, material deprivation, accommodation type) and lifestyle indicators (e.g. smoking, physical activity, walking pace, tea intake, and dietary changes) with risk of developing severe COVID-19 MESHD symptoms. Blood ( cystatin C HGNC, C-reactive protein HGNC, gamma glutamyl transferase and alkaline phosphatase) and urine (microalbuminuria) biomarkers measured more than 10 years earlier predicted severe COVID-19 MESHD. We also confirm increased risks for several pre-existing disease outcomes (e.g. lung diseases MESHD, type 2 diabetes MESHD, hypertension MESHD, circulatory diseases, anemia MESHD, and mental disorders MESHD). Analyses on mortality were possible within a sub-group testing positive for COVID-19 MESHD infection (N =1,953) with our analyses confirming association between age, smoking status, and prior primary diagnosis of urinary tract infection MESHD.

    Evidence for SARS-CoV-2 Spike MESHD SARS-CoV-2 Spike PROTEIN Protein in the Urine of COVID-19 MESHD patients

    Authors: Santosh George; Anasuya Chattopadhyay Pal; Jacqueline Gagnon; Sushma Timalsina; Pallavi Singh; Pratap Vydyam; Muhammad Munshi; Joy E Chiu; Isaline Renard; Christina A Harden; Isabel M Ott; Anne E Watkins; Chantal B F Vogels; Peiwen Lu; Maria Tokuyama; Arvind Venkataraman; Arnau Casanovas-Massana; Anne L Wyllie; Veena Rao; Melissa Campbell; Shelli F Farhadian; Nathan D Grubaugh; Charles S Dela Cruz; Albert I Ko; Amalia Berna Perez; Elikplim H Akaho; Dennis G Moledina; Jeffrey Testani; Audrey R John; Michel Ledizet; Choukri Ben Mamoun

    doi:10.1101/2021.01.27.21250637 Date: 2021-01-31 Source: medRxiv

    SARS-CoV-2 infection MESHD has so far affected over 42 million people worldwide, causing over 1.1 million deaths. With the large majority of SARS-CoV-2 infected MESHD individuals being asymptomatic, major concerns have been raised about possible long-term consequences of the infection. We developed an antigen capture assay to detect SARS-CoV-2 spike PROTEIN protein in urine samples from COVID-19 MESHD patients whose diagnosis was confirmed by PCR from nasopharyngeal swabs (NP-PCR+). The study used a collection of 233 urine samples from 132 participants from Yale New Haven Hospital and the Childrens Hospital of Philadelphia obtained during the pandemic (106 NP-PCR+ and 26 NP-PCR-) as well as a collection of 20 urine samples from 20 individuals collected before the pandemic. Our analysis identified 23 out of 91 (25%) NP-PCR+ adult participants with SARS-CoV-2 spike PROTEIN S1 protein PROTEIN in urine (Ur-S+). Interestingly, although all NP-PCR+ children were Ur-S-, 1 NP-PCR- child was found to be positive for spike protein PROTEIN in urine. Of the 23 Ur-S+ adults, only 1 individual showed detectable viral RNA in urine. Our analysis further showed that 24% and 21% of NP-PCR+ adults have high levels of albumin and cystatin C HGNC in urine, respectively. Among individuals with albuminuria MESHD (>0.3 mg/mg of creatinine) statistical correlation could be found between albumin and spike protein PROTEIN in urine. Together, our data showed that 1 of 4 of SARS-CoV-2 infected MESHD individuals develop renal abnormalities MESHD such as albuminuria MESHD. Awareness about the long-term impact of these findings is warranted.

    Renal dysfunction MESHD and prognosis of COVID-19 MESHD patients: a hospital-based retrospective cohort study

    Authors: Hui-Xian Xiang; Ying Xiang; Jun Fei; Zheng Xu; Ling Zheng; Xiu-Yong Li; Lin Fu; Hui Zhao

    doi:10.21203/ Date: 2020-12-19 Source: ResearchSquare

    Introduction: Increasing evidence indicate that coronavirus disease 2019 MESHD ( COVID-19 MESHD) is companied by renal dysfunction MESHD. However, the association of Severe Acute Respiratory Syndrome Coronavirus-2 MESHD (SARS-CoV-2)-induced renal dysfunction MESHD with prognosis remains unclear.Materials and methods: This prospective case-cohort study analyzed 154 COVID-19 MESHD patients from the Second People’s Hospital of Fuyang City in Anhui Province. Clinical and demographic information were collected. Renal function was evaluated and its prognosis was followed up. Results: Of 154 hospitalized patients with COVID-19 MESHD, 125 were common and 29 were severe patients. On admission, 16 (10.4%) patients were with renal dysfunction MESHD. Serum creatinine and cystatin C HGNC were increased, eGFR HGNC was decreased in severe patients compared with those in common patients. Renal dysfunction MESHD was more common in severe patients. By multivariate logistic regression, male, higher age and hypertension MESHD were three importantly independent risk factors of renal dysfunction MESHD in COVID-19 MESHD patients. Follow-up study found that at least one renal function marker of 3.33% patients remained abnormal in two weeks after discharge. Conclusion: Male elderly COVID-19 MESHD patients with hypertension MESHD elevates the risk of renal dysfunction MESHD. SARS-CoV-2-induced renal dysfunction MESHD are not fully recovered in two weeks after discharge.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins

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