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SARS-CoV-2 proteins

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    Evidence of a dysregulated Vitamin D pathway in SARS-CoV-2 infected patient's lung cells

    Authors: Bijesh George; Ravikumar Amjesh; Aswathy Mary Paul; Santhosh Kumar TR; Madhavan Radhakrishna Pillai; Rakesh Kumar; Matthias M. Schneider; Sean R.A. Devenish; Georg Meisl; Adriano Aguzzi; Heike Fiegler; Tuomas P.J. Knowles; Leonie Alden; Lauren Allen; Marilyn Aram; Natalie Baker; Emily Brunt; Rebecca Cobb; Susan Fotheringham; Debbie Harris; Chelsea Kennard; Stephanie Leung; Kathryn A Ryan; Howard Tolley; Nadina Wand; Andrew White; Laura Sibley; Charlotte Sarfas; Geoff Pearson; Emma Rayner; Xiaochao Xue; Teresa Lambe; Sue Charlton; Sarah C Gilbert; Quentin Sattentau; Fergus Gleeson; Yper Hall; Simon G. P. Funnell; Sally Sharpe; Francisco Javier Salguero; Andrew R Gorringe; Miles Carroll

    doi:10.1101/2020.12.21.423733 Date: 2020-12-21 Source: bioRxiv

    Although a defective vitamin D pathway has been widely suspected to be associated in SARS-CoV-2 pathobiology, the status of the vitamin D pathway and vitamin D-modulated genes in lung cells of patients infected with SARS-CoV-2 remains unknown. To understand the significance of the vitamin D pathway in SARS-CoV-2 pathobiology, computational approaches were applied to transcriptomic datasets from bronchoalveolar lavage fluid MESHD ( BALF MESHD) cells of such patients or healthy individuals. Levels of vitamin D receptor, retinoid X receptor, and CYP27A1 HGNC in BALF MESHD cells of patients infected with SARS-CoV-2 were found to be reduced. Additionally, 107 differentially expressed, predominantly downregulated genes modulated by vitamin D were identified in transcriptomic datasets from patient's cells. Further analysis of differentially expressed genes provided eight novel genes with a conserved motif with vitamin D-responsive elements, implying the role of both direct and indirect mechanisms of gene expression by the dysregulated vitamin D pathway in SARS-CoV-2-infected MESHD cells. Network analysis of differentially expressed vitamin D-modulated genes identified pathways in the immune system, NF-KB;cytokine signaling, and cell cycle regulation as top predicted pathways that might be affected in the cells of such patients. In brief, the results provided computational evidence to implicate a dysregulated vitamin D pathway in the pathobiology of SARS-CoV-2 infection MESHD.

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MeSH Disease
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SARS-CoV-2 Proteins


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