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HGNC Genes

SARS-CoV-2 proteins

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    Identifying pathways and networks associated with the SARS-CoV-2 cell receptor ACE2 HGNC based on gene expression profiles in human tissues

    Authors: Qiushi Feng; Lin Li; Xiaosheng Wang

    doi:10.21203/rs.3.rs-34488/v1 Date: 2020-06-09 Source: ResearchSquare

    The angiotensin-converting enzyme 2 ( ACE2 HGNC) is a host cell receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has infected more than six million people worldwide and has caused more than 370,000 deaths as of May 31, 2020. An investigation of ACE2 HGNC expression in human tissues may provide insights into the mechanism of SARS-CoV-2 infection MESHD. We identified pathways associated with ACE2 HGNC expression and gene co-expression networks of ACE2 HGNC in pan-tissue based on the gene expression profiles in human tissues. We found that the pathways significantly associated with ACE2 HGNC upregulation were mainly involved in immune, stromal signature, metabolism, cell growth and proliferation, and cancer MESHD and other diseases. The number of genes having a significant positive expression correlation with ACE2 HGNC in females far exceeded that in males. The estrogen receptors ( ESR1 HGNC and ESR2 HGNC) and androgen receptor HGNC (AR) genes had a significant positive expression correlation with ACE2 HGNC in pan-tissue. Meanwhile, the enrichment levels of immune cells were positively associated with the expression levels of ESR1 HGNC and ESR2 HGNC, while they were inversely associated with the expression levels of AR in pan-tissue and in multiple individual tissues. It suggests that females are likely to have a more robust immune defense system against SARS-CoV-2 than males, partially explaining why females have better clinical outcomes of SARS-CoV-2 infections MESHD than males. Our data warrant further investigation for understanding the mechanism of SARS-CoV-2 infection MESHD.

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MeSH Disease
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SARS-CoV-2 Proteins


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