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MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

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    Activin A correlates with the worst outcomes in COVID-19 MESHD patients, and can be induced by cytokines via the IKK/ NF-kappa B HGNC pathway

    Authors: Megan McAleavy; Qian Zhang; Jianing Xu; Li Pan; Matthew Wakai; Peter J Ehmann; Matthew F. Wipperman; Tea Shavlakadze; Sara C Hamon; Anita Boyapati; Lori G Morton; Christos A Kyratsous; David J Glass

    doi:10.1101/2021.02.04.429815 Date: 2021-02-08 Source: bioRxiv

    A fraction of COVID-19 MESHD patients develop the most severe form, characterized by Acute Respiratory Disease Syndrome MESHD ( ARDS MESHD). The molecular mechanisms causing COVID-19 MESHD-induced ARDS MESHD have yet to be defined, though many studies have documented an increase in cytokines known as a "cytokine storm." Here, we demonstrate that cytokines that activate the NF-kappaB pathway can induce Activin A and its downstream marker, FLRG HGNC. In hospitalized COVID-19 MESHD patients elevated Activin A/ FLRG HGNC at baseline were predictive of the most severe longitudinal outcomes of COVID-19 MESHD, including the need for mechanical ventilation, lack of clinical improvement and all-cause mortality. Patients with Activin A/ FLRG HGNC above the sample median were 2.6/2.9 times more likely to die, relative to patients with levels below the sample median, respectively. The study indicates high levels of Activin A and FLRG HGNC put patients at risk of ARDS MESHD, and blockade of Activin A may be beneficial in treating COVID-19 MESHD patients experiencing ARDS MESHD.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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